61636-63-3Relevant academic research and scientific papers
5-Phenyl-3-ureidobenzazepin-2-ones as cholecystokinin-B receptor antagonists
Lowe III,Hageman,Drozda,McLean,Bryce,Crawford,Zorn,Morrone,Bordner
, p. 3789 - 3811 (2007/10/02)
A series of 5-phenyl-3-ureidobenzazepin-2-one cholecystokinin-B (CCK-B) receptor antagonists was synthesized using Beckmann ring expansion of a suitable 4-phenyl-1-tetralone as a key step. Structure-activity relationship studies revealed the importance of
Solvolysis of 2-Cyclohexyl-2-phenylethyl Tosylates Substituted at the Phenyl Ring
Krstic, Vera,Muskatirovic, Milan
, p. 1637 - 1650 (2007/10/02)
The solvolysis of 2-cyclohexyl-2-phenylethyl tosylates substituted at the phenyl ring by X= p-H (1), p-NO2, p-IO2, p-CN, p-COCH3, m-Cl, m-F, p-Cl, p-Br, p-CH3, and p-OCH3 (2a-k) in ethanol, acetic acid, and formic acid has been investigated.The total rate constants kt were determined and the obtained values together with corresponding Hammett ? constants were used to calculate the rate constants kΔ (for aryl-assisted reactions) and ks (for non-assisted reactions).The acetolysis values FkΔ and ks of 2-cyclohexyl-2-phenylethyl tosylate (1) at 100 deg C are in good agreement with those formerly obtained on the basis of product analysis.
