6164-47-2 Usage
Uses
Used in Pharmaceutical and Analytical Chemistry:
Protopine hydrochloride is used as a reference compound in the calibration curve preparation for the quantification of alkaloids from Fumaria capreolata using liquid chromatography coupled to diode array detection and electrospray ionization tandem mass spectrometry (LC-DAD-MS) and tandem mass spectrometry (MS/MS). This application is crucial for accurate identification and quantification of alkaloids in various samples.
Used in Cytotoxicity and Permeability Studies:
Protopine hydrochloride serves as an alkaloid in cytotoxicity and permeability studies involving carcinogenic cell lines. Its ability to inhibit the growth of certain cancer cells, such as H. pylori and prostate cancer cells, makes it a valuable compound for research in cancer biology and potential therapeutic applications.
Used in Platelet Aggregation Inhibition:
Protopine hydrochloride is used as an inhibitor of platelet aggregation induced by various agents, such as ADP, arachidonic acid, platelet-activating factor (PAF), and collagen in rabbit platelet-rich plasma. This property makes it a potential candidate for the development of anti-thrombotic drugs.
Used in Smooth Muscle Contraction Inhibition:
Protopine hydrochloride inhibits the contraction of isolated rat thoracic aorta induced by norepinephrine. It also acts as a non-selective inhibitor of ICa, IK, IK1, and INa in guinea pig ventricular myocytes. These actions suggest its potential use in the treatment of cardiovascular diseases.
Used in Anticonvulsant Research:
Protopine hydrochloride has been shown to increase latency to first seizure in a mouse model induced by pentylenetetrazole. This finding indicates its potential application in the development of anticonvulsant drugs for the treatment of epilepsy and other seizure disorders.
Biochem/physiol Actions
Protopine possesses anti-parasitic, antimicrobial and anti-inflammatory property. It mediates mitotic arrest by favoring tubulin polymerization. Protopine elicits anti-invasive effects in breast cancer tumor progression.. It also provides protection against oxidative stress-induced cell death.
Check Digit Verification of cas no
The CAS Registry Mumber 6164-47-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,1,6 and 4 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 6164-47:
(6*6)+(5*1)+(4*6)+(3*4)+(2*4)+(1*7)=92
92 % 10 = 2
So 6164-47-2 is a valid CAS Registry Number.
InChI:InChI=1/C20H19NO5.ClH/c1-21-5-4-13-7-18-19(25-10-24-18)8-14(13)16(22)6-12-2-3-17-20(15(12)9-21)26-11-23-17;/h2-3,7-8H,4-6,9-11H2,1H3;1H
