6164-67-6

Basic information

• Product Name: (+/-)-Pseudopelletierine oxime
• Synonyms: endo-9-methyl-9-azbicyclo[3,3,1]non-3-ylamine;9-AZABICYCLO[3,3,1]NONAN-3-ONE-9-METHYL-OXIME;9-METHYL-9-AZABICYCLO[3,3,1]NONAN-3-ONEOXIME;(+/-)-Pseudopelletierine oxime
• CAS NO: 6164-67-6
• Molecular Formula: C₉H₁₆N₂O
• Molecular Weight: 168.24
• EINECS: 1312995-182-4
• Product Categories: Pharmaceutical Intermediates
• Mol File: 6164-67-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 126-127 ºC
• Boiling Point: 281 ºC
• Flash Point: 124 ºC
• Appearance: /
• Density: 1.27
• PKA: 12.10±0.20(Predicted)
• CAS DataBase Reference: (+/-)-Pseudopelletierine oxime(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-Pseudopelletierine oxime(6164-67-6)
• EPA Substance Registry System: (+/-)-Pseudopelletierine oxime(6164-67-6)

Safety Data

• Hazardous Substances Data: 6164-67-6(Hazardous Substances Data)

Usage

General Description

(+/-)-Pseudopelletierine oxime is a synthetic compound derived from a natural alkaloid found in plants of the Solanaceae family. It has been studied for its potential as an antiparasitic agent, particularly for its ability to inhibit the growth and survival of a variety of parasites, including worms and protozoa. Research has shown that (+/-)-Pseudopelletierine oxime has anti-inflammatory and anti-cancer properties, and it is being investigated for its potential as a therapeutic agent for a range of diseases. Additionally, it has shown promise as a potential lead compound for the development of new drugs to combat drug-resistant parasites. Despite its potential therapeutic applications, further research is needed to fully understand the pharmacological properties and mechanisms of action of (+/-)-Pseudopelletierine oxime.

Upstream product

• 111-30-8 Glutaraldehyde 
• 552-70-5 pseudopelletierine 

Downstream Products

• 76272-41-8 endo-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine 
• 141650-55-7 (endo)-3-amino-9-methyl-9-azabicyclo[3.3.1]-nonane 
• 1313479-38-7 C₁₅H₂₇N₃O 
• 1313479-40-1 C₁₅H₂₇N₃O₂ 
• 1313479-41-2 C₁₇H₂₄N₂O₂ 
• 1313479-43-4 C₁₈H₂₆N₂O₂ 
• 1313479-44-5 C₁₈H₂₆N₂O₂ 
• 1313479-45-6 C₂₁H₂₆N₂O₂ 
• 1313479-46-7 C₂₁H₂₆N₂O₂ 
• 1313479-33-2 C₁₄H₂₇N₃O 
• 1313479-34-3 C₁₇H₂₅N₃O 
• 1313479-37-6 C₁₇H₃₃N₃O 
• 1313479-39-8 C₁₆H₂₉N₃O 
• 1313479-42-3 C₁₈H₂₆N₂O₂ 

Relevant articles and documents

Preparation method of granisetron intermediate

The invention discloses a preparation method of a granisetron intermediate. The preparation method comprises the following steps: step 1, carrying out a Mannich reaction on acetone dicarboxylic acid represented by a formula III to obtain pseudopelletierine represented by a formula IV; step 2, carrying out a reaction on the pseudopelletierine and hydroxylamine to prepare 3-pseudopelletierine oximerepresented by a formula V; and step 3, carrying out preparation by adopting one of the following schemes: (1) carrying out catalytic reduction on the 3-pseudopelletierine oxime through sodium bis(2-methoxyethoxy)aluminumhydride and Lewis acid to obtain a crude product of endo-3-amine-9-methyl-9-azabicyclo[3,3,1]nonane represented by a formula I, and directly using the crude product of endo-3-amine-9-methyl-9-azabicyclo[3,3,1]nonane to prepare granisetron, or purifying the crude product of endo-3-amine-9-methyl-9-azabicyclo[3,3,1]nonane for preparing granisetron; and (2) carrying out catalytichydrogenation reduction on the 3-pseudopelletierine oxime through Raney nickel to obtain a mixture of endo-3-amine-9-methyl-9-azabicyclo[3,3,1]nonane, purifying the mixture to obtain endo-3-amine-9-methyl-9-azabicyclo[3,3,1]nonane represented by the formula I, and using the endo-3-amine-9-methyl-9-azabicyclo[3,3,1]nonane used for preparing granisetron. The method has the advantages of mild reaction conditions, high reaction yield and low cost, and is suitable for industrial production.