61642-40-8

Basic information

• Product Name: 12-ALPHA-HYDROXYSTEROID DEHYDROGENASE
• Synonyms: 12ALPHA-HSDH;12-ALPHA-HYDROXYSTEROID DEHYDROGENASE;12ALPHA-HYDROXYSTEROID:NADP+-OXIDOREDUCTASE;EC 1.1.1.176;12A-HYDROXYSTEROID DEHYDROGENASE FROM*BA CILLUS SPHA;FromClostridiumspec.;12α-Hydroxysteroid Dehydrogenase from Bacillus sphaericus;12α-Hydroxysteroid Dehydrogenase from Clostridium sp.
• CAS NO: 61642-40-8
• Molecular Weight: 0
• Mol File: 61642-40-8.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: 12-ALPHA-HYDROXYSTEROID DEHYDROGENASE(CAS DataBase Reference)
• NIST Chemistry Reference: 12-ALPHA-HYDROXYSTEROID DEHYDROGENASE(61642-40-8)
• EPA Substance Registry System: 12-ALPHA-HYDROXYSTEROID DEHYDROGENASE(61642-40-8)

Safety Data

• Hazardous Substances Data: 61642-40-8(Hazardous Substances Data)

Usage

Description

12-Alpha-Hydroxysteroid Dehydrogenase is an enzyme that plays a vital role in the conversion of steroid hormones such as cortisol and corticosterone into their respective 12-alpha-hydroxylated forms. This enzyme is crucial for the regulation of mineralocorticoid and glucocorticoid levels in the body, which are essential for maintaining fluid and electrolyte balance and the body's response to stress. Dysregulation of 12-Alpha-Hydroxysteroid Dehydrogenase has been associated with various conditions, including hypertension, metabolic syndrome, and obesity. Understanding its function is important for developing treatments for these and other related disorders.

Uses

Used in Pharmaceutical Industry:
12-Alpha-Hydroxysteroid Dehydrogenase is used as a target for drug development for the treatment of conditions related to its dysregulation, such as hypertension, metabolic syndrome, and obesity. By modulating the activity of this enzyme, it may be possible to develop therapies that help restore the balance of mineralocorticoid and glucocorticoid levels in the body, thereby addressing the underlying causes of these disorders.
Used in Research Applications:
12-Alpha-Hydroxysteroid Dehydrogenase is used as a subject of study in research to better understand its role in the regulation of steroid hormones and its involvement in various diseases. This knowledge can contribute to the development of new diagnostic tools, therapeutic strategies, and a deeper understanding of the underlying mechanisms of related disorders.
Used in Diagnostic Industry:
12-Alpha-Hydroxysteroid Dehydrogenase can be used as a biomarker for the diagnosis and monitoring of conditions related to its dysregulation. By measuring the activity or expression levels of this enzyme, healthcare professionals may be able to identify individuals at risk for hypertension, metabolic syndrome, and obesity, as well as track the progression of these disorders and the effectiveness of treatments.