61652-71-9

Upstream product

• 75-97-8 3,3-dimethyl-butan-2-one 
• 103-71-9 phenyl isocyanate 
• 52323-99-6 1-bromo-4,4-dimethyl-2-pentyne 
• 100-65-2 N-Phenylhydroxylamine 
• 17094-34-7 ethyl pivaloylacetate 
• 62-53-3 aniline 

Downstream Products

• 86193-10-4 4,4-Dimethyl-3-oxo-2-[1-oxo-2,3-diphenyl-1H-indolizin-(7E)-ylidene]-pentanoic acid phenylamide 
• 182917-74-4 3-(2,2-Dimethyl-propionyl)-4-hydroxy-1-phenyl-pyrrole-2,5-dione 
• 182918-14-5 3-Chloro-4-(2,2-dimethyl-propionyl)-1-phenyl-pyrrole-2,5-dione 
• 182918-50-9 2-Azido-4-tert-butyl-6-phenyl-pyrrolo[3,4-d]pyrimidine-5,7-dione 
• 1393463-87-0 N-phenyl-2-pivaloyloxirane-2-carboxamide 
• 1387590-17-1 (R)-N-phenyl-2-pivaloyloxirane-2-carboxamide 
• 1387590-67-1 4,4-dimethyl-2-methylene-3-oxo-N-phenylpentanamide 

Relevant academic research and scientific papers

Copper-Catalyzed Aerobic Oxidations of 3-N-Hydoxyaminoprop-1-ynes to Form 3-Substituted 3-Amino-2-en-1-ones: Oxidative Mannich Reactions with a Skeletal Rearrangement

Cu-catalyzed aerobic oxidations of readily available 3-N-hydroxyaminopro-1-ynes with water, alcohols, or thiols to form diverse 3-substituted 3-amino-2-en-1-ones are described. The utility of this catalysis is manifested by a wide scope of applicable N-hydroxyl propargylamines and nucleophiles, thus enabling the design of one-pot cascade or two-step sequential reactions. Besides synthetic significances, such oxidative Mannich reactions are mechanistically interesting because structurally reorganized products were obtained. Our mechanistic studies reveal that the aerobic oxidations involve initial formation of nitrone intermediates, followed by the attack of nucleophiles. Herein, water and MeOH implement the conversion of nitrone intermediates to reaction products in two distinct pathways. Go Mannich! Cu-catalyzed aerobic oxidations of 3-N-hydroxyaminopro-1-ynes with water, alcohols, or thiols to form diverse 3-substituted 3-amino-2-en-1-ones are reported (see scheme). Such oxidative Mannich reactions are mechanistically interesting, because structurally reorganized products were obtained.

Highly enantioselective epoxidation catalyzed by cinchona thioureas: Synthesis of functionalized terminal epoxides bearing a quaternary stereogenic center

A brilliant debut! Cinchona thioureas have been reported for the first time as catalysts in the area of asymmetric oxidations. They efficiently promote an unprecedented highly enantioselective epoxidation of deactivated 1,1-disubstituted alkenes to terminal epoxides containing a quaternary stereogenic center (see scheme). Copyright

A NEW SYNTHESIS OF β-KETO AMIDES VIA REACTION OF KETONE LIZHIUM ENOLATES WITH ISOCYANATES

A series of β-ketoamides was prepared by a convenient new method involving addition of various isocyanates to lithium enolates of acetophenone propiophenone and pinacolone.