61656-43-7Relevant articles and documents
Synthesis and biological evaluation of fluoro-substituted spiro-isoxazolines as potential anti-viral and anti-cancer agents
Boone, Sarah,Das, Prasanta,Hamme, Ashton T.,Mitra, Dipanwita,Raucher, Drazen,Tandon, Ritesh,Turner, Lindsay
, p. 30223 - 30237 (2020/09/03)
Electrophilic fluorine-mediated dearomative spirocyclization has been developed to synthesize a range of fluoro-substituted spiro-isoxazoline ethers and lactones. The in vitro biological assays of synthesized compounds were probed for anti-viral activity
Oxonium ion-mediated synthesis of 4-substituted spiro-isoxazolines
McClendon, Eric,Omollo, Ann O.,Valente, Edward J.,Hamme II, Ashton T.
body text, p. 533 - 535 (2009/04/14)
The stereoselective synthesis of 4-bromo-spiro-isoxazolines was achieved in one step through the bromination of various isoxazoles that contain a pendant alcohol or carboxylic acid functional group. Isoxazole bromination leads to a bromonium ion intermedi