61661-19-6

Basic information

• Product Name: 4H-1-Benzopyran-4-one, 3-[[4-(dimethylamino)phenyl]methylene]-2,3-dihydro-
• CAS NO: 61661-19-6
• Molecular Formula: C18H17NO2
• Molecular Weight: 279.338
• Mol File: 61661-19-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-4-one, 3-[[4-(dimethylamino)phenyl]methylene]-2,3-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-4-one, 3-[[4-(dimethylamino)phenyl]methylene]-2,3-dihydro-(61661-19-6)
• EPA Substance Registry System: 4H-1-Benzopyran-4-one, 3-[[4-(dimethylamino)phenyl]methylene]-2,3-dihydro-(61661-19-6)

Safety Data

• Hazardous Substances Data: 61661-19-6(Hazardous Substances Data)

Upstream product

• 491-37-2 2,3-dihydro-4H-1-benzopyran-4-one 
• 100-10-7 4-dimethylamino-benzaldehyde 

Downstream Products

• 76238-54-5 3-[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-chroman-4-ol 

Relevant articles and documents

Synthesis and biological evaluation of 3-benzylidene-4-chromanone derivatives as free radical scavengers and α-glucosidase inhibitors

A series of 3-benzylidene-4-chromanone derivatives (3-20) were synthesized and the structure-activity relationships for antioxidant and α-glucosidase inhibitory activities were evaluated. Among synthesized compounds, compounds 5, 13, 18, which contain catechol moiety, showed the potent 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity (5: EC50 13 μM; 13: EC50 14 μM; 18: EC50 13 μM). The compounds 12, 14, 18 showed higher α-glucosidase inhibitory activity (12: IC50 15 μM; 14: IC50 25 μM; 18: IC50 28 μM). The compound 18 showed both of potent DPPH radical scavenging and α-glucosidase inhibitory activities. These data suggest that 3-benzylidene-4-chromanone derivatives, such as compound 18, may serve as the lead compound for the development of novel α-glucosidase inhibitors with antioxidant activity.

Structural studies of seven homoisoflavonoids, six thiohomoisoflavonoids, and four structurally related compounds

1H and 13C NMR chemical shifts have been determined and assigned based on PFG 1H, 13C HM...C, and HMBC experiments for 3-(4'-X-benzyl)-4-chromenones (Ia, X = CN and Ib, X = NO 2), 3-(4'-X-benzyl)-4-th

Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells

A series of 3-benzylidene-4-chromanones 1a-l were prepared and their cytotoxicity towards human Molt 4/C8 and CEM T-lymphocytes as well as murine L1210 lymphoid leukemia cells were compared to the previously generated biodata in these three assays for the