616868-63-4Relevant academic research and scientific papers
Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity
Zhao, Zhijian,Robinson, Ronald G.,Barnett, Stanley F.,Defeo-Jones, Deborah,Jones, Raymond E.,Hartman, George D.,Huber, Hans E.,Duggan, Mark E.,Lindsley, Craig W.
, p. 49 - 53 (2008/09/21)
This letter describes the development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved aqueous solubility (～18 mg/mL) that translates into enhanced cell activity and caspase-3 induction.
