61693-42-3

Usage

Uses

Used in Pharmaceutical Industry:
3-amino-2,4-dichlorophenol is utilized as an active pharmaceutical ingredient for the development of various medications. Its unique chemical structure allows it to be a key component in the synthesis of drugs that address a range of health conditions.
Used in Dye Industry:
In the dye industry, 3-amino-2,4-dichlorophenol is employed as a precursor in the production of dyes. Its chemical properties enable the creation of a variety of colorants used in textiles, plastics, and other materials.
Used in Organic Synthesis:
3-amino-2,4-dichlorophenol serves as an intermediate in the synthesis of various organic compounds. Its reactivity and functional groups make it a valuable building block for the creation of complex organic molecules.
Used in Agrochemical Industry:
As an intermediate in the synthesis of agrochemicals, 3-amino-2,4-dichlorophenol contributes to the development of products that protect crops from pests and diseases, thereby ensuring agricultural productivity.
Used in Antioxidant Production:
3-amino-2,4-dichlorophenol is used in the production of antioxidants, which are essential in various applications to prevent the oxidation of materials, thereby extending their shelf life and maintaining their quality.
Used in Disinfectant Formulation:
Leveraging its antiseptic and antimicrobial properties, 3-amino-2,4-dichlorophenol is used in the formulation of disinfectants. It helps to sanitize surfaces and equipment, reducing the risk of infection in various settings, such as healthcare facilities and food processing plants.
Used in Preservative Formulation:
3-amino-2,4-dichlorophenol is also used in the creation of preservatives, which are crucial for maintaining the freshness and safety of food products, cosmetics, and other consumer goods by inhibiting the growth of microorganisms.
It is crucial to handle 3-amino-2,4-dichlorophenol with care due to its potential harmful effects if ingested, inhaled, or absorbed through the skin, emphasizing the need for proper safety measures during its use and production.

InChI:InChI=1/C6H5Cl2NO/c7-3-1-2-4(10)5(8)6(3)9/h1-2,10H,9H2

Upstream product

• 38902-87-3 3-nitro-2,4-dichlorophenol 

Relevant academic research and scientific papers

The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity

Deregulation of the receptor tyrosine kinase RET has been implicated in medullary thyroid cancer, a small percentage of lung adenocarcinomas, endocrine-resistant breast cancer and pancreatic cancer. There are several clinically approved multi-kinase inhibitors that target RET as a secondary pharmacology but additional activities, most notably inhibition of KDR, lead to dose-limiting toxicities. There is, therefore, a clinical need for more specific RET kinase inhibitors. Herein we report our efforts towards identifying a potent and selective RET inhibitor using vandetanib 1 as the starting point for structure-based drug design. Phenolic anilinoquinazolines exemplified by 6 showed improved affinities towards RET but, unsurprisingly, suffered from high metabolic clearance. Efforts to mitigate the metabolic liability of the phenol led to the discovery that a flanking substituent not only improved the hepatocyte stability, but could also impart a significant gain in selectivity. This culminated in the identification of 36; a potent RET inhibitor with much improved selectivity against KDR.

Highly selective hydrogenation of aromatic chloronitro compounds to aromatic chloroamines with ionic-liquid-like copolymer stabilized platinum nanocatalysts in ionic liquids

Platinum nanoparticles (PtNPs stabilized by an ionic-liquid-like-copolymer (IP) immobilized in various ionic liquids (ILs)) effectively catalyze the selective hydrogenation of aromatic chloronitro compounds to aromatic chloroamines, a reaction of considerable commercial significance. The preparation of 2,4-dichloro-3-aminophenol (DAP) has been primarily studied due to its important industrial applications. DAP is usually prepared from 2,4-dichloro-3-nitrophenol (DNP) by reduction with hydrogen using Ni- or Pt-based catalysts. Compared to reactions in molecular (organic) solvents, the ILs system provides superior selectivity with functionalized ILs containing an alcohol group demonstrating the best recyclability, and ultimately achieving a turnover number of 2025 which is 750 fold higher than Raney nickel catalyst. A universal catalyst-ionic liquid system for the conversion of aromatic chloronitro compounds to aromatic chloroamines was also established. TEM, XPS, IR spectroscopy were used to characterize the morphology of the nanocatalysts allowing their structure to be correlated to their activity.