61705-89-3

Basic information

• Product Name: N-(2-METHOXY-PHENYL)-GUANIDINE
• Synonyms: N-(2-METHOXY-PHENYL)-GUANIDINE;1-(2-Methoxyphenyl)guanidine
• CAS NO: 61705-89-3
• Molecular Formula: C₈H₁₁N₃O
• Molecular Weight: 165.19
• Mol File: 61705-89-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2-METHOXY-PHENYL)-GUANIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-METHOXY-PHENYL)-GUANIDINE(61705-89-3)
• EPA Substance Registry System: N-(2-METHOXY-PHENYL)-GUANIDINE(61705-89-3)

Safety Data

• Hazardous Substances Data: 61705-89-3(Hazardous Substances Data)

Usage

General Description

N-(2-Methoxy-phenyl)-guanidine, also known as Methylguanidine, is a chemical compound with the molecular formula C8H11N3O. It is categorized as an organic compound and a guanidine derivative. N-(2-METHOXY-PHENYL)-GUANIDINE is commonly used as a catalyst in organic chemical reactions and as a reagent in the synthesis of other organic compounds. It is also used as a building block in the production of pharmaceuticals and agricultural chemicals. N-(2-Methoxy-phenyl)-guanidine is a white to off-white crystalline solid that is soluble in organic solvents and has a melting point of approximately 138-139°C. It is important to handle this compound with caution as it can be harmful if ingested, inhaled, or in contact with skin and eyes.

Upstream product

• 420-04-2 CYANAMID 
• 90-04-0 2-methoxy-phenylamine 
• 134-29-2 2-methoxyaniline hydrochloride 

Downstream Products

• 110149-92-3 (2-methoxy-phenylcarbamimidoyl)-amidophosphoric acid diphenyl ester 
• 1610886-08-2 5-(2-((2-methoxyphenyl)amino)pyrimidin-4-yl)-3,4-dimethylthiazol-2(3H)-one 

Relevant articles and documents

Discovery of CDK5 Inhibitors through Structure-Guided Approach

Specific abrogation of cyclin-dependent kinase 5 (CDK5) activity has been validated as a viable approach for the development of anticancer agents. However, no selective CDK5 inhibitor has been reported to date. Herein, a structure-based in silico screenin

Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors: Synthesis, SAR analysis and biological evaluation

Phosphorylation of eIF4E by human mitogen-activated protein kinase (MAPK)-interacting kinases (Mnks) is crucial for human tumourigenesis and development. Targeting Mnks may provide a novel anticancer therapeutic strategy. However, the lack of selective Mnk inhibitors has so far hampered pharmacological target validation and clinical drug development. Herein, we report, for the first time, the discovery of a series of 5-(2-(phenylamino) pyrimidin-4-yl)thiazole-2(3H)-one derivatives as Mnk inhibitors. Several derivatives demonstrate very potent Mnk2 inhibitory activity. The most active and selective compounds were tested against a panel of cancer cell lines, and the results confirm the cell-type-specific effect of these Mnk inhibitors. Detailed cellular mechanistic studies reveal that Mnk inhibitors are capable of reducing the expression level of anti-apoptotic protein Mcl-1, and of promoting apoptosis in MV4-11 acute myeloid leukaemia cells. Highly active Mnk2 inhibitors: Mnk-related cancer biology is an area of intensive research, but its inhibitor discovery has lagged behind due to a lack of understanding of the protein structure. Herein we report the discovery of Mnk2 inhibitors (e.g. 8 e). These potent and selective inhibitors are extremely valuable for target validation and drug discovery.