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Usage

Uses

Used in Organic Chemical Reactions:
N-(2-Methoxy-phenyl)-guanidine is used as a catalyst to facilitate and speed up the reactions, making it an essential component in the synthesis of various organic compounds.
Used in Pharmaceutical Production:
N-(2-Methoxy-phenyl)-guanidine serves as a building block in the production of pharmaceuticals, contributing to the development of new drugs and medications.
Used in Agricultural Chemicals:
N-(2-METHOXY-PHENYL)-GUANIDINE is also utilized as a building block in the creation of agricultural chemicals, playing a role in enhancing crop protection and yield.
Safety Precautions:
It is crucial to handle N-(2-Methoxy-phenyl)-guanidine with care, as it can be harmful if ingested, inhaled, or comes into contact with skin and eyes. Proper safety measures should be taken during its use and storage to minimize potential risks.

Upstream product

• 420-04-2 CYANAMID 
• 134-29-2 2-methoxyaniline hydrochloride 
• 90-04-0 2-methoxy-phenylamine 

Downstream Products

• 1610886-08-2 5-(2-((2-methoxyphenyl)amino)pyrimidin-4-yl)-3,4-dimethylthiazol-2(3H)-one 
• 110149-92-3 (2-methoxy-phenylcarbamimidoyl)-amidophosphoric acid diphenyl ester 

Relevant academic research and scientific papers

Discovery of CDK5 Inhibitors through Structure-Guided Approach

Specific abrogation of cyclin-dependent kinase 5 (CDK5) activity has been validated as a viable approach for the development of anticancer agents. However, no selective CDK5 inhibitor has been reported to date. Herein, a structure-based in silico screenin

One-Pot Evolution of Ageladine A through a Bio-Inspired Cascade towards Selective Modulators of Neuronal Differentiation

A bio-inspired cascade reaction has been developed for the construction of the marine natural product ageladine A and a de novo array of its N1-substituted derivatives. This cascade features a 2-aminoimidazole formation that is modeled after an arginine post-translational modification and an aza-electrocyclization. It can be effectively carried out in a one-pot procedure from simple anilines or guanidines, leading to structural analogues of ageladine A that had been otherwise synthetically inaccessible. We found that some compounds out of this structurally novel library show a significant activity in modulating the neural differentiation. Namely, these compounds selectively activate or inhibit the differentiation of neural stem cells to neurons, while being negligible in the differentiation to astrocytes. This study represents a successful case in which the native biofunction of a natural product could be altered by structural modifications.

Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors: Synthesis, SAR analysis and biological evaluation

Phosphorylation of eIF4E by human mitogen-activated protein kinase (MAPK)-interacting kinases (Mnks) is crucial for human tumourigenesis and development. Targeting Mnks may provide a novel anticancer therapeutic strategy. However, the lack of selective Mnk inhibitors has so far hampered pharmacological target validation and clinical drug development. Herein, we report, for the first time, the discovery of a series of 5-(2-(phenylamino) pyrimidin-4-yl)thiazole-2(3H)-one derivatives as Mnk inhibitors. Several derivatives demonstrate very potent Mnk2 inhibitory activity. The most active and selective compounds were tested against a panel of cancer cell lines, and the results confirm the cell-type-specific effect of these Mnk inhibitors. Detailed cellular mechanistic studies reveal that Mnk inhibitors are capable of reducing the expression level of anti-apoptotic protein Mcl-1, and of promoting apoptosis in MV4-11 acute myeloid leukaemia cells. Highly active Mnk2 inhibitors: Mnk-related cancer biology is an area of intensive research, but its inhibitor discovery has lagged behind due to a lack of understanding of the protein structure. Herein we report the discovery of Mnk2 inhibitors (e.g. 8 e). These potent and selective inhibitors are extremely valuable for target validation and drug discovery.