61712-40-1Relevant academic research and scientific papers
Phosphonium acidic ionic liquid: An efficient and recyclable homogeneous catalyst for the synthesis of 2-Arylbenzoxazoles, 2-Arylbenzimidazoles, and 2-Arylbenzothiazoles
Nguyen, Quang The,Thi Hang, Anh-Hung,Ho Nguyen, Thuy-Linh,Nguyen Chau, Duy-Khiem,Tran, Phuong Hoang
, p. 11834 - 11842 (2018/04/05)
A highly efficient and green strategy for the synthesis of 2-Arylbenzoxazoles, 2-Arylbenzimidazoles, and 2-Arylbenzothiazoles catalyzed by phosphonium acidic ionic liquid has been developed via the condensation of o-Aminophenol, o-phenylenediamines, and o-Aminothiophenol, respectively, with aldehydes. The reaction has a good yield, the broad substrate scope, and mild condition. Triphenyl(butyl-3-sulphonyl)phosphonium toluenesulfonate catalyst was easily obtained from cheap and available starting materials through a one-pot synthesis. Its structure was identified by 1H NMR, 13C NMR, 31P NMR, and FT-IR techniques. Other properties including thermal stability and acidity were determined by TGA and Hammett acidity function method. Interestingly, the catalyst can maintain its constantly outstanding performance till the fourth recovery.
Deep eutectic solvent-catalyzed arylation of benzoxazoles with aromatic aldehydes
Tran, Phuong Hoang,Thi Hang, Anh-Hung
, p. 11127 - 11133 (2018/03/26)
A novel and efficient methodology for the arylation of benzoxazoles with aromatic aldehydes catalyzed by deep eutectic solvent has been developed. The reaction smoothly proceeded with a wide range of substrates to give the desired products in high yields within short reaction time. Deep eutectic solvents are easily recovered and reused without significant loss of catalytic activity.
Benzoin oxazole derivatives, preparation method thereof and pharmaceutical compositions that contain them
-
Paragraph 0524; 0526-0529, (2021/10/23)
Benzoxazole derivatives novel benzo the present invention refers to, effect because of having immunosuppressive effect and manufacturing method thereof including obesity and obesity related metabolic diseases in particular, various diabetes and medicament for the prophylaxis or treatment of diseases associated with diabetes is directed to compositions. Benzoxazole derivatives novel benzo of the present invention a sugar-dependent insulin secretion [...] to increase the weight of an increase in the activity of suppression effect on GPR119 (G protein-coupled receptor 119) by efficiently antifungal is and lipid metabolism per, as well as diabetes, obesity, hyperlipidemia, diabetic vascular disease of a polyimide resin, such data structure for complications diabetes for prophylactic and therapeutic composition can be useful
Synthesis and pharmacological evaluation of piperidine (piperazine)-substituted benzoxazole derivatives as multi-target antipsychotics
Huang, Ling,Zhang, Wenjun,Zhang, Xiaohua,Yin, Lei,Chen, Bangyin,Song, Jinchun
supporting information, p. 5299 - 5305 (2015/11/09)
The present study describes the optimization of a series of novel benzoxazole-piperidine (piperazine) derivatives combining high dopamine D2 and serotonin 5-HT1A, 5-HT2A receptor affinities. Of these derivatives, the pharm
