61714-27-0 Usage
Uses
Used in Pharmaceutical Industry:
W-7 HYDROCHLORIDE is used as a calmodulin antagonist for its ability to bind to calmodulin and inhibit Ca2+/calmodulin-regulated enzyme activities. This makes it a valuable tool in studying the role of calmodulin in various cellular processes and potential therapeutic applications.
Used in Cardiovascular Research:
W-7 HYDROCHLORIDE is used as a vascular relaxing agent for its effect on vascular smooth muscle actomyosin. It produces relaxation of isolated rabbit arterial strips and antagonizes the contraction of the strips induced by various contractile agonists, making it useful in studying vascular function and the development of treatments for cardiovascular diseases.
Used in Cell Biology Research:
W-7 HYDROCHLORIDE is used as a research tool for studying the effect of calmodulin inhibition on coated pit staining. This helps researchers understand the role of calmodulin in cellular processes such as endocytosis and vesicle trafficking.
Biological Activity
Calmodulin antagonist. Inhibits Ca 2+ -calmodulin-dependent phosphodiesterase (IC 50 = 28 μ M) and myosin light chain kinase (IC 50 = 51 μ M).
Biochem/physiol Actions
Cell permeable: yes
Check Digit Verification of cas no
The CAS Registry Mumber 61714-27-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,7,1 and 4 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 61714-27:
(7*6)+(6*1)+(5*7)+(4*1)+(3*4)+(2*2)+(1*7)=110
110 % 10 = 0
So 61714-27-0 is a valid CAS Registry Number.
InChI:InChI=1/C16H21ClN2O2S/c17-15-9-5-8-14-13(15)7-6-10-16(14)22(20,21)19-12-4-2-1-3-11-18/h5-10,19H,1-4,11-12,18H2/p+1
