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Usage

Uses

Used in Pharmaceutical Industry:
2-CHLORO-3-NITROTHIOPHENE-5-SULFONAMIDE is used as an intermediate in the synthesis of various pharmaceuticals for its potential applications in the development of new drugs. Its chemical structure and properties make it suitable for further research and development, particularly in the fields of antimicrobial and antiparasitic agents.
Used in Agrochemical Industry:
2-CHLORO-3-NITROTHIOPHENE-5-SULFONAMIDE is also used as an intermediate in the synthesis of agrochemicals, contributing to the development of effective solutions for pest and disease control in agriculture. Its unique chemical properties allow for the creation of compounds with targeted effects on specific pests or pathogens, enhancing crop protection and yield.

InChI:InChI=1/C4H3ClN2O4S2/c5-4-2(7(8)9)1-3(12-4)13(6,10)11/h1H,(H2,6,10,11)

Downstream Products

• 1235865-17-4 (R)-5-(4-(isopropyl(methyl)amino)-1-(phenylthio)butan-2-ylamino)-4-nitrothiophene-2-sulfonamide 
• 1235865-02-7 (R)-5-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-4-nitrothiophene-2-sulfonamide 

Relevant academic research and scientific papers

STUDIES IN THE HETEROCYCLIC COMPOUNDS V. SOME REACTIONS OF 5-CHLORO-2-THIOPHENESULFONYL DERIVATIVES

The reactions of 5-chloro-2-thiophenesulfonyl chloride are described.Treatment of the sulfonyl chloride with ammonia, hydrazine hydrate, sodium azide, indole and imidazole gave the sulfonamides (5), sulfonohydrazide (4), sulfonyl azide (3), 1-(5-chloro-2-thiophenesulfonyl)indole (27) and 1-(5-chloro-2-thiophenesulfonyl)-imidazole (26), respectively.The sulfonyl chloride was reacted further with 20 aryl and cycloalkyl-amines to give the corresponding sulfonamides (6)-(25).Attempted chlorination of the sulfonyl chloride (2) with sulfuryl chloride or bromination of the sulfonyl azide (3) with pyridinium bromide perbromide failed.However, nitration of the sulfonyl chloride (2) with fuming nitric acid gave the 4-nitro-sulfonyl chloride (28), which with sodium azide afforded the 5-chloro-4-nitro-sulfonyl azide (29).The sulfonyl azides, (3) and (29), have been reacted with triphenylphosphine, triethylphosphite, norbornene and cyclohexene.The azides reacted further with indole and 1-methylindole to give the 2-sulfonyliminoindoles (34)-(36).The infrared spectra and mass spectra of some of the substituted thiophenesulfonyl derivatives are discussed.