61714-46-3

Basic information

• Product Name: 2-CHLORO-3-NITROTHIOPHENE-5-SULFONAMIDE
• Synonyms: BUTTPARK 27\04-08;2-CHLORO-3-NITROTHIOPHENE-5-SULFONAMIDE;2-CHLORO-3-NITROTHIOPHENE-5-SULPHONAMIDE;5-chloro-4-nitrothiophene-2-sulfonamide
• CAS NO: 61714-46-3
• Molecular Formula: C₄H₃ClN₂O₄S₂
• Molecular Weight: 242.66
• Mol File: 61714-46-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 160 °C
• Boiling Point: 471 °C at 760 mmHg
• Flash Point: 238.6 °C
• Appearance: /
• Density: 1.843 g/cm³
• Vapor Pressure: 4.83E-09mmHg at 25°C
• Refractive Index: 1.652
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-CHLORO-3-NITROTHIOPHENE-5-SULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-3-NITROTHIOPHENE-5-SULFONAMIDE(61714-46-3)
• EPA Substance Registry System: 2-CHLORO-3-NITROTHIOPHENE-5-SULFONAMIDE(61714-46-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 61714-46-3(Hazardous Substances Data)

Usage

General Description

2-CHLORO-3-NITROTHIOPHENE-5-SULFONAMIDE is a chemical compound that contains a chlorine atom, a nitro group, and a sulfonamide group attached to a thiophene ring. It is a yellow crystalline solid that is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2-CHLORO-3-NITROTHIOPHENE-5-SULFONAMIDE has potential applications in the development of new drugs, particularly in the field of antimicrobial and antiparasitic agents. Its chemical structure and properties make it suitable for further research and development in the pharmaceutical industry.

InChI:InChI=1/C4H3ClN2O4S2/c5-4-2(7(8)9)1-3(12-4)13(6,10)11/h1H,(H2,6,10,11)

Downstream Products

• 1235865-17-4 (R)-5-(4-(isopropyl(methyl)amino)-1-(phenylthio)butan-2-ylamino)-4-nitrothiophene-2-sulfonamide 
• 1235865-02-7 (R)-5-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-4-nitrothiophene-2-sulfonamide 

Relevant articles and documents

STUDIES IN THE HETEROCYCLIC COMPOUNDS V. SOME REACTIONS OF 5-CHLORO-2-THIOPHENESULFONYL DERIVATIVES

The reactions of 5-chloro-2-thiophenesulfonyl chloride are described.Treatment of the sulfonyl chloride with ammonia, hydrazine hydrate, sodium azide, indole and imidazole gave the sulfonamides (5), sulfonohydrazide (4), sulfonyl azide (3), 1-(5-chloro-2-thiophenesulfonyl)indole (27) and 1-(5-chloro-2-thiophenesulfonyl)-imidazole (26), respectively.The sulfonyl chloride was reacted further with 20 aryl and cycloalkyl-amines to give the corresponding sulfonamides (6)-(25).Attempted chlorination of the sulfonyl chloride (2) with sulfuryl chloride or bromination of the sulfonyl azide (3) with pyridinium bromide perbromide failed.However, nitration of the sulfonyl chloride (2) with fuming nitric acid gave the 4-nitro-sulfonyl chloride (28), which with sodium azide afforded the 5-chloro-4-nitro-sulfonyl azide (29).The sulfonyl azides, (3) and (29), have been reacted with triphenylphosphine, triethylphosphite, norbornene and cyclohexene.The azides reacted further with indole and 1-methylindole to give the 2-sulfonyliminoindoles (34)-(36).The infrared spectra and mass spectra of some of the substituted thiophenesulfonyl derivatives are discussed.