6172-50-5 Usage
Uses
Used in Pharmaceutical Industry:
Plumbagin is used as an active pharmaceutical ingredient for its antitumor properties, targeting various types of cancer cells and exhibiting potential synergistic effects when combined with conventional chemotherapeutic drugs. Its ability to modulate multiple oncological signaling pathways contributes to its therapeutic potential in cancer treatment.
Used in Antimicrobial Applications:
In the field of antimicrobials, plumbagin serves as an antibacterial and antifungal agent, effectively combating a range of microbial infections. Its broad-spectrum activity makes it a valuable candidate for the development of new antimicrobial drugs to address the growing issue of drug resistance.
Used in Anti-inflammatory Applications:
Plumbagin is utilized as an anti-inflammatory agent, demonstrating efficacy in reducing inflammation and associated symptoms in various inflammatory diseases. Its ability to modulate inflammatory pathways and alleviate inflammatory responses positions it as a potential therapeutic option for inflammatory conditions.
Used in Antimalarial Applications:
In the context of antimalarial drug development, plumbagin is explored for its potential to treat malaria, a disease caused by Plasmodium parasites. Its antimalarial properties offer a promising avenue for the development of new treatments to combat this global health challenge.
Used in Anti-aging and Antioxidant Research:
Plumbagin is also being investigated for its potential as an anti-aging and antioxidant agent, with research focusing on its ability to protect against oxidative stress and promote cellular health. This application could lead to the development of novel age-delaying and health-promoting products.
Check Digit Verification of cas no
The CAS Registry Mumber 6172-50-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,1,7 and 2 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 6172-50:
(6*6)+(5*1)+(4*7)+(3*2)+(2*5)+(1*0)=85
85 % 10 = 5
So 6172-50-5 is a valid CAS Registry Number.
InChI:InChI=1/C19H14O5/c1-24-13-9-7-12(8-10-13)15-18(22)16(20)14(17(21)19(15)23)11-5-3-2-4-6-11/h2-10,20,23H,1H3
6172-50-5Relevant academic research and scientific papers
Discovery of a potent, highly selective, and orally efficacious small-molecule activator of the insulin receptor
Liu,Xu,Szalkowski,Li,Ding,Kwei,Huskey,Moller,Heck,Zhang,Jones
, p. 3487 - 3494 (2007/10/03)
A series of 3,6-diaryl-2,5-dihydroxybenzoquinones were synthesized and evaluated for their abilities to selectively activate human insulin receptor tyrosine kinase (IRTK). 2,5-Dihydroxy-6-(1-methylindol-3-yl)-3-phenyl-1,4-benzoquinone (2h) was identified
Synthesis of Grevillins, Novel Pyrandione Pigments of Fungi. Biogenetic Interrelationships between Grevillins, Pulvinic Acids, Terphenylquinones and Xylerythrins
Pattenden, Gerald,Pegg, Neil A.,Kenyon, Ronald W.
, p. 2363 - 2372 (2007/10/02)
A synthesis of the grevillin group of pyrandione pigments, e.g. 3, 23 and 24 present in fungi is described.The synthesis, which is based on a biogenetic model, uses bis-benzylacyloins 9 and their corresponding oxalate derivatives as key intermediates (Scheme 3).Treatment of the grevillins 25a-c with sodium ethoxide in ethanol effects their quantitative isomerisation into the corresponding terphenylquinone pigments 4a-c.Perkin-type condensations between the terphenylquinones 4 and arylacetic acids in the presence of sodium acetate-acetic anhydride then produces the xylerythrin pigments 29a-e, whereas rearrangements of 4 in the presence of dimethyl sulphoxide leads to pulvinic acid derivative, e.g. 31, 32 and 5.These synthetic studies interrelate the biosynthetic origins of the pigment types 3, 4, 5 and 8 together with the related pulvinones 6 and furanone 7 fungal pigments.
SYNTHESIS OF GREVILLINS AND THEIR BIOGENETIC INTERRELATIONSHIP WITH TERPHENYLQUINONES, XYLERYTHRINS AND PULVINIC ACIDS
Pattenden, Gerald,Pegg, Neil A.,Kenyon, Ronald W.
, p. 4749 - 4752 (2007/10/02)
A synthesis of the grevillin group , of pigments present in fungi, using benzylacyloins, viz (9), as key intermediates is described, and the biogenetic interrelationships between them and the terphenylquinone, xylerythrin and pulvinic acid families of natural colouring matter, are exemplified with the in vitro conversions (16)-(17), (17)-(20) and (17)-(22).
