61728-55-0

Upstream product

• 762-42-5 dimethyl acetylenedicarboxylate 
• 14491-02-2 2,2-dimethyl-3-phenyl-2H-azirine 
• 56062-73-8 iodure de N,N,N-trimethyl hydrazonium de l'isobutyrophenon 

Downstream Products

• 104156-50-5 dimethyl 1,2,2-trimethyl-5-phenyl-3-pyrroline-3,4-dicarboxylate 
• 104156-47-0 1,2,2-trimethyl-5-phenyl-3,4-bis<<(N-2-propylcarbamoyl)oxy>methyl>-3-pyrroline 
• 104156-46-9 1,2,2-trimethyl-5-phenyl-3,4-bis(hydroxymethyl)-3-pyrroline 

Relevant academic research and scientific papers

Synthesis and Antineoplastic Activity of Bisoxy>methyl>-Substituted 3-Pyrrolines as Prodrugs of Tumor Inhibitory Pyrrole Bis(carbamates)

A series of bispyrrolines 2-4 were synthesized from either the appropriate α-silylated iminium salt, or an aziridine, or a 2H-azirine in a sequence involving 1,3-dipolar cycloaddition reactions.The antineoplastic activities of the pyrrolines were compared to the corresponding pyrroles.The C-2 gem-dimethyl-substituted pyrroline, 4, which cannot be converted to the pyrrole in vivo, was inactive.The activity of the 2-phenyl-substituted pyrrolines 3 was markedly dependent on the nature of the phenyl substituent, although the correspondingphenylpyrroles all showed comparable activity.The differences in the activities of the pyrrolines 3 may be due to the rate of metabolic conversion of the pyrroline to the pyrrole.Electron-withdrawing substituents on the phenyl ring appear to retard this process.