61741-42-2Relevant academic research and scientific papers
The method of synthesis of quinazolinone derivative
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Paragraph 0026; 0027; 0028; 0029; 0030, (2019/03/26)
The invention discloses a method for synthesizing quinazolinone derivatives, from the commercialization or easy synthesis of 2 - amino quinazolinone starting, by carrying out the alkylation reaction of the alcohol, the obtained quinazolinone derivatives.
Ligand-free palladium assisted insertion of isocyanides to urea derivatives for cascade synthesis of phenylamino-substituted quinazolinones
Sharma, Siddharth,Jain, Abhilasha
, p. 6051 - 6054 (2015/01/09)
Palladium catalyzed cascade coupling of substituted urea derivatives and tert-butyl isocyanide for the efficient synthesis of phenylamino-substituted quinazolinones has been developed in moderate to good yields. This method provides a short and alternative approach for the synthesis of quinazolinones derivatives which are valuable compounds with biological and pharmacological potentials. A plausible mechanistic scheme is proposed.
Odorless isocyanide chemistry: An integrated microfluidic system for a multistep reaction sequence
Sharma, Siddharth,Maurya, Ram Awatar,Min, Kyoung-Ik,Jeong, Guan-Young,Kim, Dong-Pyo
supporting information, p. 7564 - 7568 (2013/07/26)
Can't smell this: An integrated continuous-flow microfluidic setup enables in situ generation, extraction, separation, and reaction of foul-smelling isocyanides with little exposure to the surroundings. Isocyanides were generated by dehydration of the corresponding N-substituted formamides, and several representative isocyanide-based organic reactions were successfully performed. DIPEA=N,N-diisopropylethylamine. Copyright
