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61752-10-1

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61752-10-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 61752-10-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,7,5 and 2 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 61752-10:
(7*6)+(6*1)+(5*7)+(4*5)+(3*2)+(2*1)+(1*0)=111
111 % 10 = 1
So 61752-10-1 is a valid CAS Registry Number.

61752-10-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name benzyl 6-oxopyran-3-carboxylate

1.2 Other means of identification

Product number -
Other names Cumalinsaeurebenzylester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:61752-10-1 SDS

61752-10-1Relevant articles and documents

Design and synthesis of 1,4-dihydropyridine derivatives as BACE-1 inhibitors

Choi, Soo-Jeong,Cho, Joong-Heui,Im, Isak,Lee, So-Deok,Jang, Ji-Yeon,Oh, Yu-Min,Jung, Yong-Keun,Jeon, Eun-Seok,Kim, Yong-Chul

experimental part, p. 2578 - 2590 (2010/07/08)

BACE-1 has been shown to be an attractive therapeutic target in Alzheimer's disease (AD). Using a 1,4-dihydropyridine (DHP) scaffold, we synthesized new inhibitors of BACE-1 by modifying the known BACE inhibitor 2 containing a hydroxyethylamine (HEA) motif. Using structure-based drug design based on computer-aided molecular docking, the isophthalamide ring of 2 was replaced with a 1,4-dihydropyridine ring as a brain-targeting strategy. Several of the new dihydropyridine derivatives were synthesized and their BACE-1-inhibitory activities were evaluated using a cell-based, reporter gene assay system that measures the cleavage of alkaline phosphatase (AP)-APP fusion protein by BACE-1. Most of the 1,4-DHP analogs showed BACE-1-inhibitory activities with IC50 values in the range 8-30?μM, suggesting that the 1,4-DHP skeleton may be utilized to develop brain-targeting BACE-1 inhibitors.

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