61758-79-0Relevant academic research and scientific papers
Synthesis of sulfonic acid derivatives by oxidative deprotection of thiols using tert-butyl hypochlorite
Joyard, Yoann,Papamicael, Cyril,Bohn, Pierre,Bischoff, Laurent
, p. 2294 - 2297 (2013)
Starting from alkyl halides or Michael acceptors, thioacetates were prepared in situ and further treated with t-BuOCl, affording the corresponding sulfonyl chlorides which were trapped with nucleophiles such as water, alcohol, or amines. The three steps can be achieved in a one-pot procedure. Oxidative deprotection also proved to be efficient with S-trityl and S-tert-butyl groups, making it a convenient route toward cysteic acid derivatives.
