61765-46-6Relevant academic research and scientific papers
Diastereo- and Enantioselective Cross-Couplings of Secondary Alkylcopper Reagents with 3-Halogeno-Unsaturated Carbonyl Derivatives
Kremsmair, Alexander,Skotnitzki, Juri,Knochel, Paul
supporting information, p. 11971 - 11973 (2020/09/07)
Chiral secondary alkylcopper reagents were prepared from the corresponding alkyl iodides with retention of configuration by an I/Li-exchange using tBuLi (?100 °C, 1 min) followed by a transmetalation with CuBr?P(OEt)3 (?100 °C, 20 s). These ste
Palladium-Catalyzed Ullmann Cross-Coupling of β-Iodoenones and β-Iodoacrylates with o-Halonitroarenes or o-Iodobenzonitriles and Reductive Cyclization of the Resulting Products to Give Diverse Heterocyclic Systems
Khan, Faiyaz,Dlugosch, Michael,Liu, Xin,Khan, Marium,Banwell, Martin G.,Ward, Jas S.,Carr, Paul D.
supporting information, p. 2770 - 2773 (2018/05/22)
The palladium-catalyzed Ullmann cross-coupling of β-iodoenones and β-iodoacrylates such as 5 (X = I) with o-halonitroarenes and o-iodobenzonitriles including 2 affords products such as compound 7. These can be engaged in a range of reductive cyclization r
HETEROCYCLIC COMPOUND
-
Paragraph 0581, (2016/09/26)
The problem of the present invention is to provide a compound having a PDE2A inhibitory action, and useful as a prophylactic or therapeutic drug for schizophrenia, Alzheimer's disease and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
Generation and trapping of cyclopentenylidene gold species: Four pathways to polycyclic compounds
Lemiere, Gilles,Gandon, Vincent,Cariou, Kevin,Hours, Alexandra,Fukuyama, Takahide,et al.
supporting information; experimental part, p. 2993 - 3006 (2009/09/04)
Cyclopentenylidene gold complexes can easily be formed from vinyl allenes through a Nazarov-like mechanism. Such carbenes may transform in four different ways into polycyclic frameworks: electrophilic cyclopropanation, C-H insertion, C-C migration, or proton shift. We have studied the selectivity of these different pathways and used our findings for the expedient preparation of valuable complex molecules. An application to the total synthesis of a natural product, Δ9(12)-capnellene,is presented. DFT computations were carried out to shed light on the me chanisms.
BENZAMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE
-
Page/Page column 148, (2008/06/13)
The invention relates to the inhibition of histone deacetylase. The invention provides compounds which are derivatives of benzamide and suitable in methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions .
Competition among 1,2- and 1,3-Acyl Shifts, and Reduction Reactions, in the UV Irradiation of Cyclopent-2-enones bearing a C-3 Terminal-alkyne Chain
Mancini, Ines,Cavazza, Marino,Guella, Graziano,Pietra, Francesco
, p. 2181 - 2186 (2007/10/02)
UV irradiation in MeCN of 3-(pent-4'-ynyl)cyclopent-2-enone 13 (prepared from 3-iodocyclopent-2-enone 12 and the cuprate obtained from 5-iodopent-1-yne 10a) gave mainly hydrogen-addition product of the primary photocycloadduct 15, tricyclo3,7>decan-4-one 18a (56percent), besides minor 16 (22percent), 19 (12percent), 17 (8percent) and traces of 15 (2percent).In acetone as solvent, formation of 18a remained the main route owing, presumably, to strain release on hydrogen addition in the primary photocycloadduct 15.In CD3CN as solvent, photoconversion of 13 was slower, deuterium was incorporated at the tertiary bridgheads in the reduction product 18b, and the product balance was slightly in favour of the 1,2-acyl-shift product 16.This situation was not substantially ameliorated even in the typically reduction-hindering solvent hexadeuterioacetone.UV irradiation of the side-chain homologous 3-(hex-5'-ynyl)cyclopent-2-enone 14 in MeCN led to mainly the products of photocycloaddition (tricyclo3,7>undec-10-en-7-one 20) and 1,3-acyl-shift (tricyclo1,6>undec-10-en-7-one 21), albeit in modest yields, 12 and 24percent, respectively.
Synthesis of β-chloro, β-bromo, and β-iodo α,β-unsaturated ketones
Piers, Edward,Grierson, John R.,Lau, Cheuk Kun,Nagakura, Isao
, p. 210 - 223 (2007/10/02)
A new, efficient method for the preparation of β-chloro, β-bromo, and β-iodo α,β-unsaturated ketones is described.The method involves the reaction of β-diketones or α-hydroxymethylenecycloalkanones with triphenylphosphine dihalides in the presence of trie
