617688-30-9Relevant academic research and scientific papers
Novel antibiotics: macrocyclic peptides designed to trap Holliday junctions.
Bolla, Megan L,Azevedo, Enrique V,Smith, Jason M,Taylor, Rachel E,Ranjit, Dev K,Segall, Anca M,McAlpine, Shelli R
, p. 109 - 112 (2007/10/03)
[reaction: see text] Described are the syntheses of eight macrocyclic peptides designed to trap Holliday junctions in bacteria, thereby inhibiting bacterial growth. These macrocycles were designed from linear dimerized hexapeptides that bind to the C-2 sy
