617688-67-2Relevant academic research and scientific papers
Synthesis and anti-inflammatory activity evaluation of unsymmetrical selenides
Martinez-Ramos, Federico,Salgado-Zamora, Hector,Campos-Aldrete, Maria Elena,Melendez-Camargo, Estela,Marquez-Flores, Yazmin,Soriano-Garcia, Manuel
, p. 1432 - 1437 (2008/09/21)
The alkylation reaction of 2,2′-diseleno and 4,4′-diseleno-bis(benzoic acid) derivatives in the presence of sodium borohydride and alkyl halides allowed the synthesis of various new o- and p-alkylselenenylated benzoic acid derivatives in good yields. The anti-inflammatory activity of selected selenide derivatives on granuloma induced by subcutaneous implantation of cotton pellets in Wistar rats was examined. Selenium derivatives 2a, 2c and 2e showed anti-inflammatory activity although to a lesser extent as compared to indomethacin, however they were found less toxic than the latter.
