617688-75-2

Upstream product

• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 500213-35-4 (S)-2-{[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl]-amino}-3-phenyl-propionic acid methyl ester 
• 500213-34-3 (S)-tert-butyl 3-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 617685-48-0 (S)-3-Phenyl-2-[((S)-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl)-amino]-propionic acid methyl ester 
• 115962-35-1 (3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinole-3-carboxylic acid 

Relevant academic research and scientific papers

Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC

Holliday junctions (HJs) are formed as transient DNA intermediates during site-specific and homologous recombination. Both of these genetic exchange pathways are critical for normal DNA metabolism and repair. Trapping HJs leads to bacterial cell death by

Novel antibiotics: macrocyclic peptides designed to trap Holliday junctions.

[reaction: see text] Described are the syntheses of eight macrocyclic peptides designed to trap Holliday junctions in bacteria, thereby inhibiting bacterial growth. These macrocycles were designed from linear dimerized hexapeptides that bind to the C-2 sy