617691-16-4

Basic information

• Product Name: 2-Propenoic acid, 3-[4-[[[4-(1-pyrrolidinyl)benzoyl]amino]methyl]phenyl]-, ethyl ester, (2E)-
• CAS NO: 617691-16-4
• Molecular Formula: C23H26N2O3
• Molecular Weight: 378.471
• Mol File: 617691-16-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-[4-[[[4-(1-pyrrolidinyl)benzoyl]amino]methyl]phenyl]-, ethyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-[4-[[[4-(1-pyrrolidinyl)benzoyl]amino]methyl]phenyl]-, ethyl ester, (2E)-(617691-16-4)
• EPA Substance Registry System: 2-Propenoic acid, 3-[4-[[[4-(1-pyrrolidinyl)benzoyl]amino]methyl]phenyl]-, ethyl ester, (2E)-(617691-16-4)

Safety Data

• Hazardous Substances Data: 617691-16-4(Hazardous Substances Data)

Upstream product

• 617691-15-3 N-(4-hydroxymethylbenzyl)-4-pyrrolidin-1-ylbenzamide 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 617691-17-5 N-(4-formyl-benzyl)-4-pyrrolidin-1-yl-benzamide 
• 39895-56-2 4-hydroxymethyl-benzylamine 
• 22090-27-3 4-(pyrrolidine-1-yl)benzoic acid 

Relevant articles and documents

Synthesis and Biological Evaluation of 3-(4-Substituted-phenyl)-N-hydroxy-2-propenamides, a New Class of Histone Deacetylase Inhibitors

Inhibitors of histone deacetylases (HDACs) have been shown to induce differentiation and/or apoptosis of human tumor cells. Novel 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides have been prepared as a new class of HDAC inhibitors and evaluated for their antiproliferative activity and HDAC inhibitory activity. Incorporation of a 1,4-phenylene carboxamide linker, shown by 5, and a 4-(dimethylamino)phenyl or 4-(pyrrolidin-1-yl)phenyl group as a cap substructure generated highly potent hydroxamic acid-based HDAC inhibitors 5a and 5b.