617693-34-2Relevant academic research and scientific papers
A new strategy for construction of eight-membered carbocycles by Brook rearrangement mediated [6 + 2] annulation
Takeda, Kei,Haraguchi, Hidekazu,Okamoto, Yasushi
, p. 3705 - 3707 (2003)
(Matrix presented) A newly developed strategy for construction of eight-membered carbocycles via [6 + 2] annulation that involves the combination of β-alkenoyl acylsilanes and a vinyllithium derivative is described. A unique feature of this annulative approach is that it enables in one operation and a stereoselective manner construction of eight-membered ring systems containing useful functionalities for further synthetic elaboration from readily available six- and two-carbon components.
