618070-51-2

Upstream product

• 35322-20-4 ethyl 3-(4-methoxybenzoyl)pyruvate 
• 60-34-4 methylhydrazine 
• 938182-54-8 ethyl 5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylate 
• 74-88-4 methyl iodide 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 1609174-01-7 N-(4-(2-(diethylamino)ethoxy)phenyl)-3-(4-methoxyphenyl)-1-methyl-1H-pyrazole-5-carboxamide 
• 93618-34-9 3-(4-methoxyphenyl)-1-methyl-1H-pyrazole-5-carboxylic acid 
• 1609174-02-8 N-(4-(3-(diethylamino)propoxy)phenyl)-3-(4-methoxyphenyl)-1-methyl-1H-pyrazole-5-carboxamide 
• 1609174-03-9 N-(2-butoxy-4-(3-(diethylamino)propoxy)phenyl)-3-(4-methoxyphenyl)-1-methyl-1H-pyrazole-5-carboxamide 
• 852816-08-1 ethyl 3-(4-hydroxyphenyl)-1-methyl-1H-pyrazole-5-carboxylate 

Relevant academic research and scientific papers

Novel heteroarylcarboxamide derivative or pharmacutically acceptable salt thereof, process for the preparation thereof and pharmaceutical composition for prevention or treatment of RAGE receptor related diseases containing the same as an active ingredient

The present invention refers to novel heterocyclic biting Carbox probably the id derivative acceptable salt, and manufacturing method thereof including RAGE associated active acetylcholinesterase receptor or pharmaceutical composition for preventing or treating disease is directed to. Heterocycle by the present invention a derivative biting Carbox probably the id RAGE receptor antagonism in by, nerve cells with the beta loss oh with wheat id RAGE conjunction with receptor, inhibiting moving into brain, the resulting beta Amyloid plaque formed 21 is known to effectively inhibit generation.. Furthermore, memory a chemicals that are important in the acetylcholine for decomposing an aromatic thus inhibiting acetylcholine s reel sacrifice , RAGE disease associated active acetylcholinesterase receptor or Alzheimer's disease, cerebrovascular dementia, dementia due to damage bean curd, multi blockade dementia, Alzheimer's disease or the like dementia alcoholic or mixed dementia multi blockade and including dementia, pick (pick) bottle, a smartcrew [...] -Jakob (Creutzfeldt-jakob) bottle, that thyroid gland symptoms , bean curd a blade Parkinson (Parkinson) bottle, Huntington's disease (Huntington) which is useful in preventing or treating, can be used.

Pyrazole-5-carboxamides, novel inhibitors of receptor for advanced glycation end products (RAGE)

In an effort to develop novel inhibitors of receptor for advanced glycation end products (RAGE) for the treatment of Alzheimer's disease, a series of pyrazole-5-carboxamides were designed, synthesized and biologically evaluated. Analyses of the extensive

SUBSTITUTED PYRAZOLES AS PPAR AGONISTS

A compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof (I) wherein: p is O or 1; q is O or 1; R1 and R2 are independently H or C1-3 alkyl; R3 and R4 are independently H, C1-6 alkyl, -OC1-6 alkyl, halogen, OH, C2-6 alkenyl or CF3; R5 is H, C1-6 alkyl (optionally substituted by one or more halogens, -COphenyl, OC1-6 alkyl, phenyl morpholino or C2-6 alkenyl. R6 is C1-6 alkyl, halogen, -OCH2 phenyl, phenyl (optionally substituted by C1-3 alkiyl), morpholino, pyrrolidino, piperidino, thiophenyl, furanyl pyridinyl or -OC2-6 alkenyl. These compounds activate the alpha and gamma subtypes fo the hppar receptor and are useful e.g. in the treatment of diabetes, dyslipidemia or syndrome X.