618070-56-7Relevant articles and documents
Synthesis, X-ray crystal structure and fluorescent spectra of novel pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives
Zheng, Liang-Wen,Gong, Zhong-Liang,Liu, Wen-Long,Liu, Ying-Rui,Zhao, Bao-Xiang
body text, p. 372 - 379 (2011/12/02)
A series of fluorescent compounds, containing pyrazolo[1,5-a]pyrazin-4(5H)- one moiety, were designed and synthesized from ethyl 1-(2-oxo-2-phenylethyl)-3- phenyl-1H-pyrazole-5-carboxylates. The structures of the compounds have been confirmed by IR,
Synthesis of novel oxime-containing pyrazole derivatives and discovery of regulators for apoptosis and autophagy in A549 lung cancer cells
Zheng, Liang-Wen,Li, Ying,Ge, Di,Zhao, Bao-Xiang,Liu, Ying-Rui,Lv, Hong-Shui,Ding, Jun,Miao, Jun-Ying
supporting information; experimental part, p. 4766 - 4770 (2010/10/04)
A series of novel oxime-containing pyrazole derivatives were synthesized by the reaction of ethyl 3-phenyl-1H-pyrazole-5-carboxylate derivatives and 2-bromo-1-phenylethanone followed by the reaction with hydroxylamine hydrochloride. The structures were determined by IR, 1H NMR, HRMS, and X-ray analysis. A dose- and time-dependent inhibition of proliferation was observed in A549 lung cancer cell after compound treatment. Inhibition of growth was mainly attributed to the autophagy induction.
