618070-56-7Relevant academic research and scientific papers
Synthesis, X-ray crystal structure and fluorescent spectra of novel pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives
Zheng, Liang-Wen,Gong, Zhong-Liang,Liu, Wen-Long,Liu, Ying-Rui,Zhao, Bao-Xiang
body text, p. 372 - 379 (2011/12/02)
A series of fluorescent compounds, containing pyrazolo[1,5-a]pyrazin-4(5H)- one moiety, were designed and synthesized from ethyl 1-(2-oxo-2-phenylethyl)-3- phenyl-1H-pyrazole-5-carboxylates. The structures of the compounds have been confirmed by IR,
Synthesis, crystal structure and biological evaluation of novel 2-(5-(hydroxymethyl)-3-phenyl-1H-pyrazol-1-yl)-1-phenylethanol derivatives
Zheng, Liang-Wen,Zhu, Jian,Zhao, Bao-Xiang,Huang, Yao-Hui,Ding, Jun,Miao, Jun-Ying
scheme or table, p. 5792 - 5799 (2011/02/26)
A series of novel 2-(5-(hydroxymethyl)-3-phenyl-1H-pyrazol-1-yl)-1- phenylethanol derivatives (4) was synthesized from ethyl 1-(2-oxo-2-phenylethyl) -3-phenyl-1H-pyrazole-5-carboxylate derivatives (3) and characterized by means of IR, 1H NMR, HRMS and X-ray crystal diffraction. Structures of 4a, 4d, 4e and 4f were also determined by 13C NMR. Isomeric intermediates, 3a and 5a, were unambiguously confirmed by X-ray crystal structure analysis and successfully differentiated with 1H NMR chemical shifts of methylene bonded to pyrazole ring. Preliminary biological evaluation showed that compounds 4d and 4e could suppress A549 lung cancer cell growth through cell cycle arrest and autophagy.
Synthesis of novel oxime-containing pyrazole derivatives and discovery of regulators for apoptosis and autophagy in A549 lung cancer cells
Zheng, Liang-Wen,Li, Ying,Ge, Di,Zhao, Bao-Xiang,Liu, Ying-Rui,Lv, Hong-Shui,Ding, Jun,Miao, Jun-Ying
supporting information; experimental part, p. 4766 - 4770 (2010/10/04)
A series of novel oxime-containing pyrazole derivatives were synthesized by the reaction of ethyl 3-phenyl-1H-pyrazole-5-carboxylate derivatives and 2-bromo-1-phenylethanone followed by the reaction with hydroxylamine hydrochloride. The structures were determined by IR, 1H NMR, HRMS, and X-ray analysis. A dose- and time-dependent inhibition of proliferation was observed in A549 lung cancer cell after compound treatment. Inhibition of growth was mainly attributed to the autophagy induction.
