618092-44-7Relevant academic research and scientific papers
Pyrazole amide derivative as well as preparation method and application thereof
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Paragraph 0037; 0040-0041; 0128-0129; 0131; 0132-0133; ..., (2022/04/03)
The invention discloses a preparation method and an application of a 1-substituent-5-substituent-N '-(1-disubstituent)-1H-pyrazole-4-formyl hydrazine derivative (general formula I) and a 1-methyl-5-substituent-1H-pyrazole-4-formyl amino acid methyl ester derivative (general formula II), wherein the 1-substituent-5-substituent-N'-(1-disubstituent)-1H-pyrazole-4-formyl hydrazine derivative (general formula I) and the 1-methyl-5-substituent-1H-pyrazole-4-formyl amino acid methyl ester derivative (general formula II) can inhibit plant growth and in-vitro HPPD target enzyme. The invention relates to the technical field of chemical engineering and pesticides. The specific technology is that the compound can effectively inhibit growth of broadleaf weed purslane rhizomes and also shows excellent inhibitory activity on HPPD enzyme. The compound B7 in the 1-methyl-5-substituent-1H-pyrazole-4-formyl amino acid methyl ester derivative disclosed by the invention has a 100% inhibition rate on the roots and stems of purslane under the dosage of 100 [mu] g/mL, and even has 77.39% and 64.93% inhibition rates on the roots and stems of purslane under the dosage of 10 [mu] g/mL, which are superior to topramezone (53.96% and 43.0%). The compound provided by the invention can be developed and used as a potential HPPD inhibitor and a broadleaf weed pre-emergence herbicide, and has the advantages of simple structure, simple preparation process, low production cost and wide application prospect.
