618095-90-2

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 1017246-21-7 tert-butyl((2R,3S,4S,E)-6-cyclohexyl-3-methoxy-2,4-dimethylhex-5-enyloxy)diphenylsilane 
• 108393-30-2 (2R,3R,4R)-5-(benzyloxy)-2,4-dimethyl-1,3-pentanediol 
• 618096-13-2 (2S,3S,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-3-methoxy-2,4-dimethyl-pentan-1-ol 

Downstream Products

• 618095-93-5 (2R,3R,4S,5RS,8S,9S,10S,11S,12S)-13-benzyloxy-1-tert-butyldiphenyl-silyloxy-9,11-isopropylidenedioxy-3-methoxy-2,4,8,10,12-penta-methyl-6-tridecyn-5-ol 
• 1440422-55-8 C₃₆H₅₂O₃Si₂ 
• 1440422-56-9 C₃₆H₅₂O₃Si₂ 
• 1450877-74-3 C₂₈H₄₀O₂Si 
• 1440422-45-6 (4S,5R,6S,7R,8R,Z)-9-((tert-butyldiphenylsilyl)oxy)-4-(dimethyl(phenyl)silyl)-7-methoxy-6,8-dimethylnon-2-en-5-ol 
• 1383995-80-9 (4S,5S,6S,7R,8R)-9-((tert-butyldiphenylsilyl)oxy)-7-methoxy-4,6,8-trimethylnon-2-yn-5-ol 
• 1360864-56-7 (3S,4S,5S,6R,7R)-8-((tert-butyldiphenylsilyl)oxy)-6-methoxy-3,5,7-trimethyloct-1-en-4-ol 
• 1360864-50-1 (3R,4R,5S,6R,7R)-8-((tert-butyldiphenylsilyl)oxy)-6-methoxy-3,5,7-trimethyloct-1-en-4-ol 
• 618096-14-3 (2R,3R,4S,8S)-8-[(4S,5S,6S)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-1-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-2,4-dimethyl-nonan-5-ol 
• 618095-96-8 (2S,3S,4S,5S,6S,9RS,10S,11R,12R)-13-tert-butyldiphenylsilyloxy-3,5-isopropylidenedioxy-11-methoxy-2,4,6,10,12-pentamethyl-1,9-tridecanediol 
• 618096-15-4 (2R,3R,4S,5S,6S,10R,11R,12R)-13-tert-butyldiphenylsilyloxy-3,5-isopropylidenedioxy-11-methoxy-2,4,6,10,12-pentamethyl-9-oxotridecanal 

Relevant academic research and scientific papers

Asymmetric catalysis route to anti,anti stereotriads, illustrated by applications

(Chemical Equation Presented) A short sequence based on asymmetric catalysis, chirality transfer, and an optimized carbometallation protocol gave an anti,anti stereotriad building block in six steps. Both enantiomers of the chirality source, N-methyl ephedrine, are inexpensive, and the auxiliary is recoverable. In one chiral series, the building block was converted to the B-2 intermediate in Miyashita's synthesis of scytophycin C; in the enantiomeric series, it was converted to a key intermediate for aplyronine A and to the polyketide cap for the callipeltins.

Total synthesis of scytophycin C. 1. Stereoselective syntheses of the C(1)-C(18) segment and the C(19)-C(31) segment

[Equation presented] Stereoselective total synthesis of scytophycin C, a marine 22-membered macrolide displaying potent activity against a variety of human carcinoma cell lines, has been reported in which the polypropionate structure bearing contiguous as