618098-63-8 Usage
Explanation
The molecular formula represents the number of atoms of each element present in a molecule of the compound.
Explanation
The molecular weight is the mass of one mole of the compound, calculated by adding the atomic weights of all the atoms in the molecular formula.
Explanation
This describes the arrangement of atoms and the type of chemical bonds in the compound.
Explanation
The compound is derived from the pyrazole ring, which is a five-membered ring containing four carbon atoms and one nitrogen atom.
Explanation
The compound contains an aldehyde group (-CHO), which is a carbonyl group bonded to a hydrogen atom.
Explanation
The compound has a chlorine atom attached to the phenyl ring.
Explanation
The compound contains a p-tolyl group, which is a methyl group (-CH3) attached to the 4th position of a phenyl ring.
Explanation
The compound is used in various chemical and pharmaceutical applications, such as the synthesis of other compounds or as an intermediate in drug development.
Explanation
The compound may have potential biological activities, which could be explored for therapeutic or diagnostic purposes.
Explanation
The exact uses and properties of the compound may differ based on the specific application it is used for and the formulation in which it is incorporated.
Molecular weight
302.75 g/mol
Chemical structure
1-(3-chlorophenyl)-3-p-tolyl-1H-pyrazole-4-carbaldehyde
Pyrazole derivative
Yes
Aldehyde functional group
Present
Chlorine atom
One
p-Tolyl group
Present
Applications
Chemical and pharmaceutical
Potential biological activities
Yes
Specific uses and properties
Vary depending on application and formulation
Check Digit Verification of cas no
The CAS Registry Mumber 618098-63-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,1,8,0,9 and 8 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 618098-63:
(8*6)+(7*1)+(6*8)+(5*0)+(4*9)+(3*8)+(2*6)+(1*3)=178
178 % 10 = 8
So 618098-63-8 is a valid CAS Registry Number.
618098-63-8Relevant academic research and scientific papers
FARNESOID X RECEPTOR ANTAGONISTS
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Paragraph 0320, (2015/09/23)
Provided herein are Farnesoid X receptor (FXR) antagonists, methods of antagonizing FXR, and methods of treating metabolic disease using the antagonists herein.
Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor
Yu, Donna D.,Lin, Wenwei,Forman, Barry M.,Chen, Taosheng
, p. 2919 - 2938 (2014/05/20)
Farnesoid X receptor (FXR, NRIH4) plays a major role in the control of cholesterol metabolism. This suggests that antagonizing the transcriptional activity of FXR is a potential means to treat cholestasis and related metabolic disorders. Here we describe the synthesis, biological evaluation, and structure-activity relationship (SAR) studies of trisubstituted-pyrazol carboxamides as novel and potent FXR antagonists. One of these novel FXR antagonists, 4j has an IC50 of 7.5 nM in an FXR binding assay and 468.5 nM in a cell-based FXR antagonistic assay. Compound 4j has no detectable FXR agonistic activity or cytotoxicity. Notably, 4j is the most potent FXR antagonist identified to date; it has a promising in vitro profile and could serve as an excellent chemical tool to elucidate the biological function of FXR.
