618113-61-4

Upstream product

• 67752-36-7 (1-methyl-1,2,3,4-tetrahydroquinolin-2-yl)-methanol 
• 5344-90-1 2-Aminobenzyl alcohol 
• 17374-20-8 1,4-dihydro-benzo[d][1,3]oxazine-2-thione 
• 618113-49-8 carbonic acid allyl ester 2-allyloxycarbonylaminobenzyl ester 
• 618113-45-4 (2-chloromethylphenyl)carbamic acid allyl ester 
• 125447-80-5 1H,3H,3aH,4H,5H-[1,3]oxazolo[3,4-a]quinolin-1-one 
• 345201-68-5 prop-2-en-1-yl N-[2-(hydroxymethyl)phenyl]carbamate 

Relevant academic research and scientific papers

Design, synthesis, and evaluation of tetrahydroquinoline-linked thiazolidinedione derivatives as pparγ selective activators

A series of tetrahydroqninoline-linked thiazolidinediones was designed and synthesized and their peroxisome proliferator activated receptor-γ (PPARγ) agonistic activities were evaluated. A number of analogs were revealed to have significant PPARγ agonisti

The aza-xylylene Diels-Alder approach for the synthesis of naturally occurring 2-alkyl tetrahydroquinolines

The recently discovered intramolecular aza-xylylene Diels-Alder reaction, based on a 1,4-dehydrohalogenation reaction, was extended in terms of substrates and leaving groups allowing the assembly of tetrahydroquinolines in two synthetic steps. Intramolecular cleavage of a thiocarbamate using triphenylphosphine and tetrachloromethane (Appel conditions) to give chloromethyl phenylisocyanate has been presented for the first time. The synthetic feasibility of this process was demonstrated in the first total syntheses of the alkaloids rac-Angustureine and 1-methyl-2-propyltetrahydroquinoline.