618403-11-5Relevant academic research and scientific papers
Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain
Drizin, Irene,Gregg, Robert J.,Scanio, Marc J.C.,Shi, Lei,Gross, Michael F.,Atkinson, Robert N.,Thomas, James B.,Johnson, Matthew S.,Carroll, William A.,Marron, Brian E.,Chapman, Mark L.,Liu, Dong,Krambis, Michael J.,Shieh, Char-Chang,Zhang, XuFeng,Hernandez, Gricelda,Gauvin, Donna M.,Mikusa, Joseph P.,Zhu, Chang Z.,Joshi, Shailen,Honore, Prisca,Marsh, Kennan C.,Roeloffs, Rosemarie,Werness, Stephen,Krafte, Douglas S.,Jarvis, Michael F.,Faltynek, Connie R.,Kort, Michael E.
, p. 6379 - 6386 (2008/12/22)
The synthesis and pharmacological characterization of a novel furan-based class of voltage-gated sodium channel blockers is reported. Compounds were evaluated for their ability to block the tetrodotoxin-resistant sodium channel Nav1.8 (PN3) as
