61841-34-7

Usage

Uses

Used in Polymer Synthesis:
Benzoxazole, 2-(1-methylethenyl)is used as a starting material for the anionic polymerization of 2-vinylbenzoxazole and 2-isopropenylbenzoxazole. Its unique structure allows for the formation of novel block copolymers with potential applications in various industries.
Used in Chemical Industry:
In the chemical industry, Benzoxazole, 2-(1-methylethenyl)is utilized as an intermediate for the synthesis of new block copolymers. These copolymers can exhibit a range of properties, such as improved mechanical strength, thermal stability, and chemical resistance, making them suitable for various applications, including coatings, adhesives, and composite materials.
Used in Pharmaceutical Industry:
Although not explicitly mentioned in the provided materials, the unique chemical structure of Benzoxazole, 2-(1-methylethenyl)-, may also make it a potential candidate for the development of new pharmaceutical compounds. Its ability to form copolymers could be leveraged to create drug delivery systems or novel therapeutic agents with enhanced properties and targeted delivery profiles.

Upstream product

• 3331-55-3 N-(2-hydroxy-phenyl)-2-methyl-acrylamide 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 122433-29-8 1-(benzo[d]oxazol-2-yl)ethanone 
• 615-18-9 2-chloro-1,3-benzoxazole 
• 126726-62-3 2-isopropenyl-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane 
• 273-53-0 benzoxazole 
• 557-93-7 2-bromoprop-1-ene 

Downstream Products

• 1373277-66-7 3-((7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylic acid 
• 1373278-88-6 tert-butyl 3-((7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)cyclobutanecarboxylate 
• 1373278-94-4 methyl 5-(7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate 
• 1373278-95-5 methyl 5-(7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate 
• 1373278-93-3 methyl 5-(7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate 

Relevant academic research and scientific papers

Room-temperature palladium-catalyzed direct 2-alkenylation of azole derivatives with alkenyl bromides

Pd-catalyzed direct C2-alkenylation of azole derivatives proceeds efficiently under mild conditions, and the reaction of substituted benzoxazoles, oxazole and benzothiazole occurred even at room temperature. The substrate scope of the reaction was turned out to include mono-, di- and trisubstituted alkenyl bromides. To validate the scalability of this method, 5-Methyl-2-(prop-1-en-2-yl)benzoxazole (3c) was prepared on one-gram scale at room temperature.

Electrochemically Enabled Carbohydroxylation of Alkenes with H2O and Organotrifluoroborates

Unprecedented hydroxy-alkynylation and -alkenylation reactions of arylalkenes have been developed through electrochemically enabled addition of an organotrifluoroborate reagent and H2O across the double bond of the alkene. The use of electrochemistry to promote these oxidative alkene 1,2-difunctionalization reactions not only obviates the need for transition-metal catalysts and oxidizing reagents but also ensures high regio- and chemoselectivity to afford homopropargylic or homoallylic alcohols. The possibility of extending the electrochemical alkene difunctionalization strategy to other alkene carbo-heterofunctionalization reactions has been demonstrated.

QUINAZOLINONE-TYPE COMPOUNDS AS CRTH2 ANTAGONISTS

This application provides for compounds of the formula Formula I or a pharmaceutically acceptable salt thereof, wherein the individual variables are defined herein, as well as processes to prepare these compounds, pharmaceutical compositions comprising the same and their use in treating disease state associated with the CRTH2 receptor.

Alkenyl bromides: useful coupling partners for the palladium-catalysed coupling with heteroaromatics via a C-H bond activation

Alkenyl bromides were found to be useful reactants for the palladium-catalysed direct C-H activation/functionalisation reaction of heteroaromatics such as benzoxazole or benzothiazole. Moderate to good yields of coupling products were obtained using both α- and β-substituted alkenyl bromides or even the trisubstituted alkenyl bromide 2-bromo-3-methylbut-2-ene. This reaction is environmentally attractive as it provides only HX associated to the base as a by-product.