61841-75-6

Upstream product

• 61915-16-0 (20S)-3β-Acetoxy-14-hydroxy-22ξ-hydroxymethyl-5β,14β-cardanolide 
• 808-19-5 digitoxigenin 3-acetate 
• 61841-73-4 (20R)-3-O-Acetyl-dihydrodigitoxigenin 
• 143-62-4 (+)-digitoxigenin 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant academic research and scientific papers

Partial Syntheses of Cardenolides and Cardenolide Analogues. VI. (20R)- and (20S)-Cardanolides

(20R)-Dihydrodigitoxigenin (2) and (20S)-dihydrodigitoxigenin (4) as well as their 3-acetates 3 and 5, respectively, were synthesized by catalytic hydrogenation of the appropriate cardenolides and separation by column chromatography on silica of the mixtures of stereoisomers.Hydroxymethylation of 3 and 5 followed by selective elimination yielded (20S)- and (20R)-14-hydroxy-22-methylene-5β,14β-cardanolide 3-acetate (10 and 16), respectively.The biological activities of the synthesized 20-stereoisomeric cardanolides are investigated and discussed.Cardanolides 10 and 16 have a strong inhibitory activity on the proliferation of Ehrlich ascites carcinoma cells in suspension culture.