618444-45-4 Usage
Uses
Used in Pharmaceutical Applications:
(3-(2,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-yl)methanol is used as a potential therapeutic agent for its demonstrated biological activity. (3-(2,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-yl)methanol is being studied for its potential applications in the pharmaceutical industry due to its unique chemical structure and the possibility of it interacting with biological targets.
Used in Research and Development:
In the field of scientific research, (3-(2,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-yl)methanol serves as a subject of study for understanding its properties, potential interactions with biological systems, and its overall safety and efficacy. This research could lead to the development of new drugs or therapies based on the compound's characteristics and effects.
Check Digit Verification of cas no
The CAS Registry Mumber 618444-45-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,1,8,4,4 and 4 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 618444-45:
(8*6)+(7*1)+(6*8)+(5*4)+(4*4)+(3*4)+(2*4)+(1*5)=164
164 % 10 = 4
So 618444-45-4 is a valid CAS Registry Number.
618444-45-4Relevant articles and documents
Synthesis, pharmacological activities and molecular docking studies of pyrazolyltriazoles as anti-bacterial and anti-inflammatory agents
Dayakar, Cherupally,Kumar, Buddana Sudheer,Sneha, Galande,Sagarika, Gudem,Meghana, Koneru,Ramakrishna, Sistla,Prakasham, Reddy Shetty,China Raju, Bhimapaka
, p. 5678 - 5691 (2017)
A series of novel pyrazolyl alcohols (5a-h), pyrazolyl azides (6a-h), and pyrazolyltriazoles (8a-h, 10a-p and 12a-l) were prepared and evaluated for their bioactivity (anti-bacterial and anti-inflammatory) profile. The compound 5c displayed the potent anti-bacterial activity against Micrococcus luteus (MIC 3.9 and MBC 7.81 μg/mL). In vitro anti-inflammatory activity data denoted that compound 8b is effective among the tested compounds against IL-6 (IC50 6.23 μM). Docking analysis of compounds 5f, 8a-b, 8e-f and 8h displayed high binding energies for the compounds 8a-b and 8h towards TNF-α dimer (2AZ5 protein) and IL-6 (1ALU protein). In vivo anti-inflammatory activity of compounds 8b and 8h with respect to LPS induced mice model indicated that compound 8h showed significant reduction in TNF-α.
