618446-32-5

Basic information

• Product Name: 2-[(4-methoxybenzyl)amino]isonicotinonitrile
• Synonyms: 2-[(4-methoxybenzyl)amino]isonicotinonitrile
• CAS NO: 618446-32-5
• Molecular Formula: C₁₄H₁₃N₃O
• Molecular Weight: 239
• Mol File: 618446-32-5.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-[(4-methoxybenzyl)amino]isonicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4-methoxybenzyl)amino]isonicotinonitrile(618446-32-5)
• EPA Substance Registry System: 2-[(4-methoxybenzyl)amino]isonicotinonitrile(618446-32-5)

Safety Data

• Hazardous Substances Data: 618446-32-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-[(4-methoxybenzyl)amino]isonicotinonitrile is used as a potential antiviral or antibacterial agent for its possible pharmaceutical properties. It is being studied for its ability to combat various viruses and bacteria, which could lead to the development of new treatments and therapies.
Used in Organic Synthesis:
In the field of organic synthesis, 2-[(4-methoxybenzyl)amino]isonicotinonitrile is used as a building block for synthesizing a range of biologically active molecules. Its unique structure allows for the creation of diverse compounds with potential applications in various industries.
Used in Medicinal Chemistry:
2-[(4-methoxybenzyl)amino]isonicotinonitrile is utilized in medicinal chemistry as a key component in the development of new drugs and pharmaceuticals. Its versatility in forming various biologically active molecules makes it a valuable asset in drug discovery and design.
Used in Material Science:
Although further research is required, 2-[(4-methoxybenzyl)amino]isonicotinonitrile may also have applications in material science. Its unique chemical properties could potentially contribute to the development of new materials with specific characteristics and uses.
Used as a Research Tool:
In the realm of organic chemistry, 2-[(4-methoxybenzyl)amino]isonicotinonitrile serves as a research tool, aiding scientists in understanding the fundamental principles of chemical reactions and the behavior of molecules. This knowledge can be applied to develop new synthetic methods and improve existing ones.

Upstream product

• 33252-30-1 2-chloro-4-pyridinenitrile 
• 2393-23-9 4-methoxy-benzylamine 
• 3939-14-8 2-fluoropyridine-4-carbonitrile 

Downstream Products

• 916765-80-5 1-(2-{[(4-methoxyphenyl)methyl]amino}pyridin-4-yl)ethan-1-one 
• 618446-33-6 (4-aminomethyl-pyridin-2-yl)-(4-methoxy-benzyl)-amine 

Relevant articles and documents

NOVEL BICYCLIC HETEROCYCLIC COMPOUND

Provided are a novel compound having a superior inhibitory action on KAT-II, a production method thereof, use thereof, and a pharmaceutical composition containing the aforementioned compound and the like. A compound represented by the formula (I) or a pharmacologically acceptable salt thereof. wherein each symbol is as defined in the DESCRIPTION.

Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors

The Rho kinases (ROCK1 and ROCK2) are highly homologous serine/threonine kinases that act on substrates associated with cellular motility, morphology, and contraction and are of therapeutic interest in diseases associated with cellular migration and contraction, such as hypertension, glaucoma, and erectile dysfunction. Beginning with compound 4, an inhibitor of ROCK1 identified through high-throughput screening, systematic exploration of SAR, and application of structure-based design, led to potent and selective ROCK inhibitors. Compound 37 represents significant improvements in inhibition potency, kinase selectivity, and CYP inhibition and possesses pharmacokinetics suitable for in vivo experimentation.

PYRIDINONE AND PYRIMIDINONE DERIVATIVES AS FACTOR XIA INHIBITORS

The present invention provides compounds of the general formula (I), their salts and N- oxides, and solvates and prodrugs thereof (wherein the characters are as defined in the description). The compounds of the general formula (I) are inhibitors of Factor XIa, so that they are useful in the prevention of and/or therapy for thromboembolic diseases.

Selective inhibitors of rock protein kinase and uses thereof

Described herein are compounds that are useful as ROCK inhibitors. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including cardiovascular, inflammatory,

SUBSTITUTED ARYL-AMINE DERIVATIVES AND METHODS OF USE

The present invention provides classes of compounds, including-their pharmaceutically acceptable derivatives, useful for treating angiogenesis and related diseases such as cancer. Formula I and II wherein R is a 9- or 10-membered heterocyclyl ring selected from 7-isoquinolinyl,..2-methyl-3-oxo-2,3-dihydroindazol-6-yl, [1,6]-naphthydrin-3-yl, [1,7]-naphthydrin-2-yl, 1-oxo-2,3-dihydrobenzofuran-4-yl, 3-oxo-2,3-dihydrobenzofuran-5-yl, dihydro-benzodioxinyl, 6-quinazolinyl, 2-amino-6-quinazolinyl, 4-methylamino-6-quinazolinyl, 2,4-diamino-6 quinazolinyl, 3-oxo-3,4-dihydro-1,4-benzoxazin-6-yl, 2,2-difluoro-l;3-benzodioxol-5-yl and 2,2,3,3 tetrafluoro-2,3-dihydro-l,4-benzodioxin-6-yl, each of which is optionally substituted with one or more substituents selected from halo, haloakyl, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, N-dimethylamino-C1-6-alkyl, N-dimethylamino-C1-6-alkoxy, amino, alkyl-carbonylamino, morpholino-sulfonyl, amino-sulfonyl, oxazolyl, pyrrolyl,4 morpholinyl, carboxyl, cyano, and acetyl; wherein R1 in formula I is selected from unsubstituted or substituted phenyl, 5-6 membered heteroaryl, 9-10 membered bicyclic heterocyclyl and 11-14 membered tricyclic heterocyclyl, and R1 in formula II is selected from specific bicyclic heterocycles.

Convenient synthesis of N-(4-(2-aminopyridin-4-yl)thiazol-2-yl)-2-phenylacetamides

We report a facile one-pot, three-step synthesis of N-(4-(2-aminopyridin-4-yl)thiazol-2-yl)-2-phenylacetamides via condensation of 2-p-methoxybenzylamino-4-acetylpyridine with phenylacetylthioureas.

Substituted alkylamine derivatives and methods of use

Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.