618453-35-3

Upstream product

• 618453-27-3 [2-Bromo-cyclohex-(E)-ylidenemethyl]-phosphonic acid diethyl ester 
• 618453-29-5 [2-Bromo-cyclohex-(Z)-ylidenemethyl]-phosphonic acid diethyl ester 
• 108-94-1 cyclohexanone 
• 39922-36-6 Cyclohexylidenmethylphosphonsaeurediaethylester 

Downstream Products

• 618453-56-8 (R)-tert-Butoxycarbonylamino-[(R)-3-(diethoxy-phosphorylmethyl)-cyclohex-2-enyl]-acetic acid ethyl ester 
• 618453-59-1 (R)-tert-Butoxycarbonylamino-[(R)-3-(diethoxy-phosphorylmethyl)-cyclohex-2-enyl]-acetic acid 
• 618453-41-1 (R)-Amino-[(R)-3-(diethoxy-phosphorylmethyl)-cyclohex-2-enyl]-acetic acid ethyl ester 

Relevant academic research and scientific papers

Diastereoselective synthesis of 3-phosphonomethyl-substituted cyclohexyl- and cyclohex-2-enylglycines

Regio- and stereoselective 1,6-additions of lithium azaenolate derived from cycto-[L-tert-Leu-Gly] 2 to (1E)- and (1Z)-cyclohex-2-enylidenemethyl phosphonates 3a,b and 4a,b allow a direct access to optically pure 3-phosphonomethyl-substituted cyclohexyl- and cyclohex-2-enylglycines 13A-C, 14A,B, 15A-C and 16A,B. Ten-membered 'compact' and 'relaxed' transition-state structures account for the stereochemical outcome of the conjugate additions.