618453-67-1

Basic information

• Product Name: (R)-tert-Butoxycarbonylamino-[(S)-3-(diethoxy-phosphorylmethyl)-cyclohex-2-enyl]-acetic acid
• CAS NO: 618453-67-1
• Molecular Weight: 405.428
• Mol File: 618453-67-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-tert-Butoxycarbonylamino-[(S)-3-(diethoxy-phosphorylmethyl)-cyclohex-2-enyl]-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-tert-Butoxycarbonylamino-[(S)-3-(diethoxy-phosphorylmethyl)-cyclohex-2-enyl]-acetic acid(618453-67-1)
• EPA Substance Registry System: (R)-tert-Butoxycarbonylamino-[(S)-3-(diethoxy-phosphorylmethyl)-cyclohex-2-enyl]-acetic acid(618453-67-1)

Safety Data

• Hazardous Substances Data: 618453-67-1(Hazardous Substances Data)

Upstream product

• 618453-65-9 (R)-tert-Butoxycarbonylamino-[(S)-3-(diethoxy-phosphorylmethyl)-cyclohex-2-enyl]-acetic acid ethyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 39922-36-6 Cyclohexylidenmethylphosphonsaeurediaethylester 
• 108-94-1 cyclohexanone 
• 618453-31-9 Cyclohex-2-en-(E)-ylidenemethyl-phosphonic acid diethyl ester 
• 618453-33-1 Cyclohex-2-en-(Z)-ylidenemethyl-phosphonic acid diethyl ester 
• 618453-29-5 [2-Bromo-cyclohex-(Z)-ylidenemethyl]-phosphonic acid diethyl ester 
• 618453-27-3 [2-Bromo-cyclohex-(E)-ylidenemethyl]-phosphonic acid diethyl ester 
• 618453-44-4 (R)-Amino-[(S)-3-(diethoxy-phosphorylmethyl)-cyclohex-2-enyl]-acetic acid ethyl ester 
• 618453-37-5 [(S)-3-((2R,5S)-5-tert-Butyl-3,6-diethoxy-2,5-dihydro-pyrazin-2-yl)-cyclohex-1-enylmethyl]-phosphonic acid diethyl ester 

Relevant articles and documents

Diastereoselective synthesis of 3-phosphonomethyl-substituted cyclohexyl- and cyclohex-2-enylglycines

Regio- and stereoselective 1,6-additions of lithium azaenolate derived from cycto-[L-tert-Leu-Gly] 2 to (1E)- and (1Z)-cyclohex-2-enylidenemethyl phosphonates 3a,b and 4a,b allow a direct access to optically pure 3-phosphonomethyl-substituted cyclohexyl- and cyclohex-2-enylglycines 13A-C, 14A,B, 15A-C and 16A,B. Ten-membered 'compact' and 'relaxed' transition-state structures account for the stereochemical outcome of the conjugate additions.