61846-16-0

Upstream product

• 396726-60-6 C₂₀H₁₈N₄O₃ 
• 7432-21-5 N-carbobenzyloxy-L-tryptophane 
• 543-27-1 isobutyl chloroformate 

Downstream Products

• 119706-40-0 methyl 5(S)-N-(benzyloxycarbonyl)amino-6-(indol-3-yl)-2-methoxycarbonyl-4-oxohexanoate 
• 119706-46-6 5(S)-N-(benzyloxycarbonyl)amino-2(RS)-(2-cyanoethyl)-6-(indol-3-yl)-4-oxohexanoic acid 
• 119706-48-8 5(S)-N-(benzyloxycarbonyl)amino-2-(RS)-(3-cyanopropyl)-6-(indol-3-yl)-4-oxohexanoic acid 
• 119706-42-2 methyl 5(S)-N-(benzyloxycarbonyl)amino-2-(2-cyanoethyl)-6-(indol-3-yl)-2-methoxycarbonyl-4-oxohexanoate 
• 119706-43-3 methyl 5(S)-N-(benzyloxycarbonyl)amino-2-(3-cyanopropyl)-2-methoxycarbonyl-6-(indol-3-yl)-4-oxohexanoate 
• 1427161-75-8 C₃₂H₃₁N₅O₂S 

Relevant academic research and scientific papers

Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives

Eighteen new hydrazino-1,3-thiazole derivatives were evaluated against 8 strains of multi-resistant Candida spp. Introduction of an indolyl moiety linked to the hydrazone function enhanced the in vitro anti-Candida activity, with an activity spectrum towards Candida albicans strains. Introduction of a (S)-2-aminoethyl chain on the thiazole nucleus largely enhanced the in vitro antifungal activity, with a selectivity oriented towards non-C. albicans species.

SYNTHESIS OF KETOMETHYLENE DIPEPTIDES CONTAINING BASIC AMINO ACID ANALOGUES AT C-TERMINUS

The four ketomethylene dipeptides Pheψ(COCH2)(RS)Orn (6a)and Trpψ(COCH2))(RS)X X=(RS)Orn (6b), (RS)Arg (8b) and (RS)Lys (12b) have been synthesized by a route involving two successive principal reactions: a malonic ester alkylation with the corresponding