61854-69-1Relevant academic research and scientific papers
An expeditious, environment-friendly, and microwave-assisted synthesis of 5-isatinylidenerhodanine derivatives
Safer, Abdelmounaim,Rahmouni, Mustapha,Carreaux, Francois,Paquin, Ludovic,Lozach, Olivier,Meijer, Laurent,Bazureau, Jean Pierre
experimental part, p. 332 - 337 (2012/02/14)
A series of nine 5-arylidenerhodanine derivatives was prepared in good yields and purity without the use of a solvent or catalyst under microwave-assisted condensation with some substituted isatins. All 5-arylidenerhodanines were evaluated as possible inhibitors of the CK1α/β, CDK5/p25, and GSK-3α/β kinases. None of them showed substantive inhibitory activity against these kinases when evaluated at the concentration of 10 μM.
Synthetic and antibacterial studies of rhodanine derivatives with indol-2,3-diones
Pardasani,Pardasani,Sherry,Chaturvedi
, p. 1275 - 1278 (2007/10/03)
A facile synthesis of new isatylidene and quinoline derivatives is described by treatment of rhodanine with indol-2,3-diones via Knoevenagel condensation and Pfitzinger reaction respectively. The reaction of indol-2,3-dione derivatives with five membered heterocycles, viz rhodanine under normal and basic conditions is described. While refluxing with ethanol it afford 3,4-dihydro-3-[2-thioxo-4-thiazolidinone]indol-2-one 3, under basic conditions 1-methyl-2-thio-4-thiazolidino[5,4-b] quinoline-4-carboxylic acid 4 is obtained. The compounds 3 and 4 have been characterized by spectral studies and elemental analyses and screened for antibacterial activity.
