61871-72-5

Basic information

• Product Name: 1-Decen-3-one, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-
• CAS NO: 61871-72-5
• Molecular Formula: C17H24O4
• Molecular Weight: 292.375
• Mol File: 61871-72-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-Decen-3-one, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Decen-3-one, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-(61871-72-5)
• EPA Substance Registry System: 1-Decen-3-one, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-(61871-72-5)

Safety Data

• Hazardous Substances Data: 61871-72-5(Hazardous Substances Data)

Usage

Molecular weight

290.39 g/mol

Structure

A long-chain ketone with a hydroxy-substituted aromatic ring

Synonyms

5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-1E-decan-3-one

Occurrence

Commonly found in plants such as ginger and turmeric

Biological activities

Has potential antioxidant and anti-inflammatory properties

Industrial uses

Used as a flavoring agent in the food and beverage industry and in the production of perfumes and other fragrances

Therapeutic applications

Has been studied for potential use in treating various diseases and conditions.

Upstream product

• 1080-12-2 (E)-4-(4-hydroxy-3-methoxyphenyl)but-3-ene-2-one 
• 66-25-1 hexanal 
• 121-33-5 vanillin 
• 130878-31-8 (E)-3-methoxy-4-trimethylsilyloxybenzylideneacetone 

Downstream Products

• 23513-14-6 (+/-)-[6]-gingerol 
• 23513-13-5 [6]-shogaol 

Relevant articles and documents

GINGEROL DERIVATIVE HAVING INHIBITORY ACTIVITY AGAINST BIOFILM FORMATION AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS EFFECTIVE INGREDIENT FOR PREVENTING OR TREATING BIOFILM-CAUSED INFECTION SYMPTOM

The present invention relates to a gingerol derivative having inhibitory activity against biofilm formation and a pharmaceutical composition for preventing or treating infections caused by biofilms including the gingerol derivative as an active ingredient. The gingerol derivative of the present invention exhibits significantly improved binding affinity for LasR and inhibitory activity against biofilm formation. Therefore, the gingerol derivative of the present invention can act on various membrane surfaces where biofilms tend to form and can effectively inhibit the formation of the corresponding biofilms. In addition, the use of the pharmaceutical composition according to the present invention can fundamentally prevent or treat a variety of infections caused by biofilms due to the presence of the gingerol derivative in the pharmaceutical composition.

Influence of side chain structure changes on antioxidant potency of the [6]-gingerol related compounds

[6]-Gingerol and [6]-shogaol are the major pungent components in ginger with a variety of biological activities including antioxidant activity. To explore their structure determinants for antioxidant activity, we synthesized eight compounds differentiated by their side chains which are characteristic of the C1-C2 double bond, the C4-C5 double bond or the 5-OH, and the six- or twelve-carbon unbranched alkyl chain. Our results show that their antioxidant activity depends significantly on the side chain structure, the reaction mediums and substrates. Noticeably, existence of the 5-OH decreases their formal hydrogen-transfer and electron-donating abilities, but increases their DNA damage- and lipid peroxidation-protecting abilities. Additionally, despite significantly reducing their DNA strand breakage-inhibiting activity, extension of the chain length from six to twelve carbons enhances their anti-haemolysis activity.