618892-02-7Relevant academic research and scientific papers
Identification of N,N-disubstituted phenylalanines as a novel class of inhibitors of hepatitis C NS5B polymerase
Chan, Laval,Reddy, T. Jagadeeswar,Proulx, Mélanie,Das, Sanjoy K.,Pereira, Oswy,Wang, Wuyi,Siddiqui, Arshad,Yannopoulos, Constantin G.,Poisson, Carl,Turcotte, Nathalie,Drouin, Alexandre,Alaoui-Ismaili, M. Hicham,Bethell, Richard,Hamel, Martine,L'Heureux, Lucille,Bilimoria, Darius,Nguyen-Ba, Nghe
, p. 1283 - 1285 (2003)
The HCV NS5B RNA dependent RNA polymerase plays an essential role in viral replication. The discovery of a novel class of inhibitors based on an N,N-disubstituted phenylalanine scaffold and structure-activity relationships studies to improve potency are described.
Further SAR studies on novel small molecule inhibitors of the hepatitis C (HCV) NS5B polymerase
Reddy, T. Jagadeeswar,Chan, Laval,Turcotte, Nathalie,Proulx, Melanie,Pereira, Oswy Z.,Das, Sanjoy K.,Siddiqui, Arshad,Wang, Wuyi,Poisson, Carl,Yannopoulos, Constantin G.,Bilimoria, Darius,L'Heureux, Lucille,Alaoui, Hicham M. A.,Nguyen-Ba, Nghe
, p. 3341 - 3344 (2007/10/03)
Herein, we describe the structure-activity relationship (SAR) of N,N-disubstituted phenylalanine series of NS5B polymerase inhibitors of hepatitis C. The NS5B polymerase inhibitory activity of the most active compound exhibited an IC50 of 2.7 μ
