6190-39-2 Usage
Uses
Used in Pharmaceutical Industry:
DIHYDROERGOTAMINE MESYLATE is used as an α-Androgenic blocker with selective venoconstrictor properties for the treatment of migraine and orthostatic hypotension. It acts as a full agonist at vascular serotonin receptors and a partial agonist at alpha-adrenergic and dopamine D2 receptors, making it effective in managing migraine symptoms.
Used in Migraine Treatment:
DIHYDROERGOTAMINE MESYLATE is used as a vasoconstrictor and antimigraine agent for the relief of migraine headaches. Its action on serotonin receptors helps to constrict blood vessels and alleviate the pain associated with migraines.
Used in Vasoconstriction:
DIHYDROERGOTAMINE MESYLATE is used as a potent vasoconstrictor in various medical applications where constriction of blood vessels is required, such as in the treatment of orthostatic hypotension.
Biological Activity
Partial α -adrenergic agonist. Partial D 2 dopaminergic receptor agonist. Competitive 5-HT antagonist.
References
Lesage et al. (1998), Agnostic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines; J. Pharmacol., 123 1655
Silberstein (1997), The pharmacology of ergotamine and dihydroergotamine; Headache, 37 Suppl 1 S15
Silberstein and McCrory (2003), Ergotamine and dihydroergotamine: history, pharmacology, and efficacy; Headache, 43 144
Lipton (1997), Ergotamine tartrate and dihydroergotamine mesylate: safety profiles; Headache, 37 Suppl.1 S33
Check Digit Verification of cas no
The CAS Registry Mumber 6190-39-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,1,9 and 0 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 6190-39:
(6*6)+(5*1)+(4*9)+(3*0)+(2*3)+(1*9)=92
92 % 10 = 2
So 6190-39-2 is a valid CAS Registry Number.
InChI:InChI=1/C33H37N5O5.CH4O3S/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32;1-5(2,3)4/h3-6,8-11,17,21,23,25-27,34,42H,7,12-16,18H2,1-2H3,(H,35,39);1H3,(H,2,3,4)/t21-,23?,25-,26+,27+,32?,33?;/m1./s1
