61904-65-2

Upstream product

• 79-19-6 thiosemicarbazide 
• 104-01-8 4-Methoxyphenylacetic acid 

Downstream Products

• 1266610-29-0 2-[(4-methoxyphenyl)methyl]thiazolo[3,2-b]-1,2,4-triazole-6-acetic acid ethyl ester 
• 1266610-32-5 2-[(4-methoxyphenyl)methyl]-6-methylthiazolo[3,2-b]-1,2,4-triazole-5-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Design and synthesis of some thiazolotriazolyl esters as anti-inflammatory and analgesic agents

In order to develop potent analgesic/antiinflammatory compounds with reduced ulcerogenic risk, a series of thiazolotriazolyl-carboxylic and acetic acid esters were synthesized and characterized by spectral and elementary analysis. All synthesized compounds were screened for in vivo anti-inflammatory activities in mice by carregeenan-induced paw edema model. The compounds showing 20% reduction in paw edema were also evaluated for their analgesic activities by acetic acid-induced writhing test and the gastric ulceration risk by determining the lipid peroxidation level in stomachs. Among the compounds tested, compounds 1, 4, 6, 7, 8, 1a, 2a, 3a, 4a, 7a, 2b, and 8b showed moderate-to-good anti-inflammatory activity at various doses in any of the measurement intervals. Compounds 7a, 2b, and 8b were the most actives of the series in analgesic activity test. Moreover, compounds 1, 4, and 8 were found to be safe in stomach in respect of free radical production. Springer Science+Business Media, LLC 2010.

2-Amino-5-(substituted or unsubstituted phenylalkyl)-thiadiazoles

2-amino-5-(substituted or unsubstituted phenylalkyl)-thiadiazoles, e.g., 2-amino-5-(4-[phenylbutyl])-thiadiazole, prepared, e.g., by ring closure, of corresponding 1-(substituted or unsubstituted phenylalkanoyl)-thiosemicarbazide in a strong acid medium.