61905-91-7

Upstream product

• 37033-95-7 5-benzyloxy-1H-indole-2-carboxylic acid ethyl ester 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 167380-79-2 ethyl 3-bromo-1-methyl-5-(phenylmethoxy)-1H-indole-2-carboxylate 
• 233758-05-9 2-(5-benzyloxy-1-methylindole)methanol 
• 167380-80-5 3-bromo-1-methyl-5-(phenylmethoxy)-1H-indole-2-carboxylic acid 
• 167380-82-7 1,1-Dimethylethyl 3-hydroxy-1-methyl-5-(phenylmethoxy)-1H-indole-2-carboxylate 
• 167380-81-6 1,1-dimethylethyl 3-bromo-1-methyl-5-(phenylmethoxy)-1H-indole-2-carboxylate 
• 167380-85-0 1-Methyl-3-(1-methylethoxy)-5-(phenylmethoxy)-1H-indole-2-carboxamide 
• 167380-84-9 1-methyl-3-(1-methylethoxy)-5-(phenylmethoxy)-1H-indole-2-carboxylic acid 
• 167380-83-8 1,1-dimethylethyl 1-methyl-3(1-methylethoxy)-5-(phenylmethoxy)-1H-indole-2-carboxylate 
• 233758-16-2 1-N-phthalimido-[2-(5-benzyloxy-1-methylindolyl)]ethylamine 
• 233758-11-7 C₂₄H₂₂N₂O₂ 
• 233758-08-2 5-benzyloxy-1-methyl-1H-indole-2-carbaldehyde O-benzyl-oxime 
• 233758-12-8 N-benzyl-N-[1-(5-benzyloxy-1-methyl-1H-indol-2-yl)-ethyl]-hydroxylamine 
• 233758-15-1 1-[2-(5-benzyloxy-1-methylindolyl)]ethanol 
• 233758-01-5 1-[2-(5-benzyloxy-1-methylindolyl)]ethylamine 

Relevant academic research and scientific papers

ANTIBACTERIAL AGENTS: ARYL MYXOPYRONIN DERIVATIVES

The invention provides compounds of formula la, lb and Ic: [Formula Ia, Ib, and Ic] and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.

Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them

Benzo-fused heterocyclic compounds having a 5-membered ring, processes for their preperation, their use as medicaments, their use as diagnostic agents and medicaments containing them. Benzo-fused heterocyclic compounds having a 5-membered ring, of the formula I STR1 where X is N or CR(6); Y is oxygen, S or NR(7); A and B together are a bond or are both hydrogen, if, at the same time, X is CR(6) and Y is NR(7), one of the substituents R(1) to R(6) is a --CO--N=C(NH2)2 group; the other respective substituents R(1) to R(6) are H, Hal or alkyl; up to two of the other substituents R(1) to R(6) are CN, NO2, N3, (C1 -C4)-alkoxy, CF3 ; up to one of the other substituents is R(8)--Cn H2n --Z-- or phenyl; R(7) is H, alk(en)yl or R(8)--Cn H2n --, and pharmaceutically tolerated salts there of, are described. A process f or the preparation of the compounds I which comprises reacting a compound of the formula II STR2 in which one of the substituents R(1)' to R(5)' is a --CO--L group and L is a leaving group which can easily be replaced nucleophilically, with guanidine, and, if appropriate, converting the product into the pharmacologically tolerated salt, furthermore is also described.

Acetylenic and allenic derivatives of 2-(5-benzyloxyindolyl) and 2-(5-hydroxyindolyl)methylamines: synthesis and in vitro evaluation as monoamine oxidase inhibitors

We report the synthesis and in vitro studies as MAO inhibitors of 2 series of new acetylenic and allenic derivatives of 2-(5-benzyloxyindolyl)- and 2-(5-hydroxyindolyl)methylamines and their indolylmethylamine precursors.All compounds were MAO inhibitors and either did not show selectivity (the benzyloxy compounds 5) or were selective for MAO-A (most of the hydroxy compounds 7).Three of the studied compounds, 7d, 7g and 7i, were found to be slightly more selective for MAO-A than clorgyline.