61919-52-6

Basic information

• Product Name: 1β-Hydroxy-6α-Methyl-1,4-androstadiene-3,17-dione
• Synonyms: 1β-Hydroxy-6α-Methyl-1,4-androstadiene-3,17-dione;Methylprednisolone Impurity 8;(6S,8S,9S,10R,11S,13S,14S)-11-hydroxy-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-dione
• CAS NO: 61919-52-6
• Molecular Formula: C₂₀H₂₆O₃
• Molecular Weight: 314.41864
• Product Categories: Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• Mol File: 61919-52-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 260-262 °C
• Boiling Point: 482.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.19±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Dioxane (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
• PKA: 14.40±0.70(Predicted)
• CAS DataBase Reference: 1β-Hydroxy-6α-Methyl-1,4-androstadiene-3,17-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1β-Hydroxy-6α-Methyl-1,4-androstadiene-3,17-dione(61919-52-6)
• EPA Substance Registry System: 1β-Hydroxy-6α-Methyl-1,4-androstadiene-3,17-dione(61919-52-6)

Safety Data

• Hazardous Substances Data: 61919-52-6(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

Different sources of media describe the Uses of 61919-52-6 differently. You can refer to the following data:
1. 11β-Hydroxy-6α-methyl-1,4-androstadiene-3,17-dione is an impurity of Methylprednisolone (M325934).
2. 1β-Hydroxy-6α-methyl-1,4-androstadiene-3,17-dione is an impurity of Methylprednisolone( M325934).

Upstream product

• 53-36-1 methylprednisolone acetate 
• 83-43-2 Methylprednisolone 

Relevant articles and documents

Radiolytic degradation scheme for 60Co-irradiated corticosteroids

The cobalt 60 radiolytic degradation products have been identified in the following corticosteroids: cortisone, cortisone acetate, hydrocortisone, hydrocortisone acetate, hydrocortisone sodium succinate, isoflupredone acetate, methylprednisolone, methylprednisolone acetate, prednisolone, prednisolone acetate, and prednisone. Two major types of degradation processes have been identified: loss of the corticoid side chain the D-ring to produce the C-17 ketone and conversion of the C-11 alcohol, if present, to the C-11 ketone. Minor degradation products derived from other changes affecting the side chain are also identified in several corticosteroids. These compounds are frequently associated in corticosteroids as process impurities or degradation compounds. No new radiolytic compounds unique to 60Co-irradiation have been found. The majority of corticosteroids have been shown to be stable to 60Co-irradiation. The rates of radiolytic degradation ranged from 0.2 to 1.4%/Mrad.