61924-52-5

Upstream product

• 626-35-7 nitroacetic acid ethyl ester 
• 32691-93-3 α,α-dimethoxy-4-fluorotoluene 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 61924-62-7 ethyl 3-(4-fluorophenyl)-2-nitropropanoate 
• 191930-41-3 (±)-ethyl 2-amino-3-(4-fluorophenyl)propanoate 
• 1448589-71-6 ethyl (2E)-3-[(ethoxycarbonyl)amino]-2-nitro-3-(4-fluorophenyl)prop-2-enoate 
• 1448589-72-7 ethyl (2Z)-3-[(ethoxycarbonyl)amino]-2-nitro-3-(4-fluorophenyl)prop-2-enoate 

Relevant academic research and scientific papers

Synthesis of unnatural α-amino esters using ethyl nitroacetate and condensation or cycloaddition reactions

We report here on the use of ethyl nitroacetate as a glycine template to produce α-amino esters. This started with a study of its condensation with various arylacetals to give ethyl 3-aryl-2-nitroacrylates followed by a reduction (NaBH4 and then zinc/HCl) into α-amino esters. The scope of this method was explored as well as an alternative with arylacylals instead. We also focused on various [2 + 3] cycloadditions, one leading to a spiroacetal, which led to the undesired ethyl 5-(benzamidomethyl)isoxazole-3-carboxylate. The addition of ethyl nitroacetate on a 5-methylene-4,5-dihydrooxazole using cerium(IV) ammonium nitrate was also explored and the synthesis of other oxazole-bearing α-amino esters was achieved using gold(I) chemistry.

One-pot multifunctional catalysis with NNN-Pincer Zr-MOF: Zr base catalyzed condensation with Rh-catalyzed hydrogenation

We describe the postsynthetic modification of Zr-based metal organic frameworks (MOFs) containing chiral NNN-pincer ligands based on aminopyridineimines, as well as the subsequent formation of (NNN)-M-Zr-MOF complexes (M=Rh, Ir). With these new multifunct