61926-46-3Relevant academic research and scientific papers
In vitro Anti-Trypanosomal Activities of Indanone-Based Chalcones
Beteck, Richard M.,Legoabe, Lesetje J.,Isaacs, Michelle,Hoppe, Heinrich C.
, p. 337 - 341 (2019)
Human African trypanosomiasis is a neglected infectious disease that affects mostly people living in the rural areas of Africa. Current treatment options are limited to just four drugs that have been in use of four to nine decades. The life-threatening to
Enhancing the Anti-Solvatochromic Two-Photon Fluorescence for Cirrhosis Imaging by Forming a Hydrogen-Bond Network
Ren, Tian-Bing,Xu, Wang,Zhang, Qian-Ling,Zhang, Xing-Xing,Wen, Si-Yu,Yi, Hai-Bo,Yuan, Lin,Zhang, Xiao-Bing
supporting information, p. 7473 - 7477 (2018/06/18)
Two-photon imaging is an emerging tool for biomedical research and clinical diagnostics. Electron donor–acceptor (D–A) type molecules are the most widely employed two-photon scaffolds. However, current D–A type fluorophores suffer from solvatochromic quenching in aqueous biological samples. To address this issue, we devised a novel class of D–A type green fluorescent protein (GFP) chromophore analogues that form a hydrogen-bond network in water to improve the two-photon efficiency. Our design results in two-photon chalcone (TPC) dyes with 0.80 quantum yield and large two-photon action cross section (210 GM) in water. This strategy to form hydrogen bonds can be generalized to design two-photon materials with anti-solvatochromic fluorescence. To demonstrate the improved in vivo imaging, we designed a sulfide probe based on TPC dyes and monitored endogenous H2S generation and scavenging in the cirrhotic rat liver for the first time.
(E)-2-Benzylidenebenzocyclanones: Part XIII - (E)/(Z)-Isomerization of some cyclic chalcone analogues. Effect of ring size on lipophilicity of geometric isomers
Perjsi, Pl
, p. 1275 - 1281 (2015/12/31)
Optimized isocratic reverse phase high-performance liquid chromatography (RP-HPLC) method was developed for separation of the respective (E) and (Z) isomers of the cyclic chalcone analogues (E)-2-(4′-X-benzylidene)-1-indanones, -tetralones, and -benzosube
Evaluation of silica-H2SO4 as an efficient heterogeneous catalyst for the synthesis of chalcones
Sultan, Aeysha,Raza, Abdul Rauf,Abbas, Muhammad,Khan, Khalid Mohammed,Tahir, Muhammad Nawaz,Saari, Nazamid
, p. 10081 - 10094 (2013/09/23)
We report an efficient silica-H2SO4 mediated synthesis of a variety of chalcones that afforded the targeted compounds in very good yield compared to base catalyzed solvent free conditions as well as acid or base catalyzed refluxing conditions.
Synthesis of some imidazolyl-substituted 2-benzylidene indanone derivatives as potent aromatase inhibitors for breast cancer therapy
Bansal, Ranju,Narang, Gaurav,Zimmer, Christina,Hartmann, Rolf W.
experimental part, p. 661 - 669 (2012/05/20)
The synthesis and aromatase inhibitory activity of a new series of 2-benzylidene indanones is presented. The imidazolyl-substituted indanones displayed potent aromatase inhibitory activity. The vanilloid-based derivative 2-[4-(3-imidazol-1-ylpropoxy)-3-me
[4+2]cycloaddition reactions involving 2-arylmethylidene-1-thiooxoindan intermediates and antimicrobial activity evaluation of some products
Hegab, Mohamed I.,Elmalah, Tamer A. G.,Gad, Farouk A.
scheme or table, p. 1665 - 1675 (2010/01/17)
2-(4-Fluorophenyl)methylidene-1-thiooxoindane-, 2-(4-methoxyphenyl) methylidene-1-thiooxoindane-, 2-(4-N,N-dimethyaminophenyl)methylidene-1- thiooxoindane dimers 5a-c were prepared by the reaction of the corresponding , -unsaturated ketones 3a-c with Lawe
