61926-50-9Relevant academic research and scientific papers
Synthesis and biological evaluation of 3-benzylidene-4-chromanone derivatives as free radical scavengers and α-glucosidase inhibitors
Takao, Koichi,Yamashita, Marimo,Yashiro, Aruki,Sugita, Yoshiaki
, p. 1203 - 1207 (2016)
A series of 3-benzylidene-4-chromanone derivatives (3-20) were synthesized and the structure-activity relationships for antioxidant and α-glucosidase inhibitory activities were evaluated. Among synthesized compounds, compounds 5, 13, 18, which contain catechol moiety, showed the potent 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity (5: EC50 13 μM; 13: EC50 14 μM; 18: EC50 13 μM). The compounds 12, 14, 18 showed higher α-glucosidase inhibitory activity (12: IC50 15 μM; 14: IC50 25 μM; 18: IC50 28 μM). The compound 18 showed both of potent DPPH radical scavenging and α-glucosidase inhibitory activities. These data suggest that 3-benzylidene-4-chromanone derivatives, such as compound 18, may serve as the lead compound for the development of novel α-glucosidase inhibitors with antioxidant activity.
Structural studies of seven homoisoflavonoids, six thiohomoisoflavonoids, and four structurally related compounds
Valkonen, Arto,Laihia, Katri,Kolehmainen, Erkki,Kauppinen, Reijo,Perjesi, Pal
experimental part, p. 209 - 217 (2012/09/07)
1H and 13C NMR chemical shifts have been determined and assigned based on PFG 1H, 13C HM...C, and HMBC experiments for 3-(4'-X-benzyl)-4-chromenones (Ia, X = CN and Ib, X = NO 2), 3-(4'-X-benzyl)-4-th
Homoisoflavonoids: Natural scaffolds with potent and selective monoamine oxidase-B inhibition properties
Desideri, Nicoletta,Bolasco, Adriana,Fioravanti, Rossella,Proietti Monaco, Luca,Orallo, Francisco,Yá?ez, Matilde,Ortuso, Francesco,Alcaro, Stefano
experimental part, p. 2155 - 2164 (2011/05/14)
A series of homoisoflavonoids [(E)-3-benzylidenechroman-4-ones 1a-w, 3-benzyl-4H-chromen-4-ones 2a-g, and 3-benzylchroman-4-ones 3a-e] have been synthesized and tested in vitro as inhibitors of human monoamine oxidase isoforms A and B (hMAO-A and hMAO-B).
Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells
Perjesi, Pal,Das, Umashankar,De Clercq, Erik,Balzarini, Jan,Kawase, Masame,Sakagami, Hiroshi,Stables, James P.,Lorand, Tamas,Rozmer, Zsuzsanna,Dimmock, Jonathan R.
, p. 839 - 845 (2008/09/20)
A series of 3-benzylidene-4-chromanones 1a-l were prepared and their cytotoxicity towards human Molt 4/C8 and CEM T-lymphocytes as well as murine L1210 lymphoid leukemia cells were compared to the previously generated biodata in these three assays for the
