619323-37-4

Basic information

• Product Name: 2-(3,4-difluorophenyl)pent-4-enoic acid
• Synonyms: 2-(3,4-difluorophenyl)pent-4-enoic acid
• CAS NO: 619323-37-4
• Molecular Weight: 212.196
• Mol File: 619323-37-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(3,4-difluorophenyl)pent-4-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-difluorophenyl)pent-4-enoic acid(619323-37-4)
• EPA Substance Registry System: 2-(3,4-difluorophenyl)pent-4-enoic acid(619323-37-4)

Safety Data

• Hazardous Substances Data: 619323-37-4(Hazardous Substances Data)

Upstream product

• 658-93-5 (3,4-difluorophenyl)acetic acid 
• 106-95-6 allyl bromide 
• 210530-71-5 (3,4-difluoro-phenyl)-acetic acid methyl ester 
• 619323-21-6 methyl 2-(3,4-difluorophenyl)pent-4-enoate 

Downstream Products

• 619323-50-1 3-(3,4-difluorophenyl)-5-methyltetrahydrofuran-2-one 

Relevant articles and documents

CHEMICAL COMPOUNDS ACTING AS PERK INHIBITORS

The invention is directed to substituted pyrrolidinone derivatives. Specifically, the invention is directed to compounds according to Formula X: wherein R41, R42, R43, R44, R45, R46, and R47 are defined herein. The compounds of the invention are inhibitors of PERK and can be useful in the treatment of cancer and diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease, stroke, diabetes, Parkinson disease, Huntington's disease, Creutzfeldt- Jakob Disease, and related prion diseases, amyotrophic lateral sclerosis, myocardial infarction, neurodegeneration, cardiovascular disease, atherosclerosis, ocular diseases, and arrhythmias, more specifically cancers of the breast, colon, pancreas and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PERK activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.