61934-77-8Relevant academic research and scientific papers
Selective C- tert -butoxycarbonylation using di- tert -butyl dicarbonate for the synthesis of multifunctional carbon compounds
Hudhomme, Pietrick
body text, p. 1331 - 1332 (2010/08/06)
The reaction of di-tert-butyl dicarbonate (Boc2O) in the presence of the acylation catalyst 4-dimethylaminopyridine (DMAP) was examined with N-Boc or N-acyl cyanoglycinate. The couple Boc2O/DMAP was found to act as an efficient agent for selective C-tert-butoxycarbonylation affording multifunctional carbon compounds.
Syntheses of bifunctional 2,3-diamino propionic acid-based chelators as small and strong tripod ligands for the labelling of biomolecules with 99mTc
Liu, Yu,Oliveira, Bruno L.,Correia, Joao D. G.,Santos, Isabel C.,Santoes, Isabel,Spingler, Bernhard,Alberto, Roger
experimental part, p. 2829 - 2839 (2010/08/20)
The labelling of targeting biomolecules requires small and hydrophilic complexes in order to not affect the binding properties of the vectors. 2,3-Diamino propionic acid (dap) is a small and strong, albeit scarcely used, tripod ligand for the fac-[99mTc(CO)3]+ moiety. We have introduced at the α-carbon atom in the basic dap structure various second functionalities such as carboxylato, amino and α-amino acid groups via various spacers in order to yield bifunctional chelators. These dap derivatives can be coupled to targeting molecules for application in molecular imaging. Full characterizations of the bifunctional chelators, X-ray structures of intermediates and of one rhenium complex, as well as labelling studies with 99mTc, are presented.
